Author(s): Borgens RB, Blight AR, Murphy DJ, Stewart L
Using an implanted battery and electrodes, we have imposed a weak, steady electrical field across partially severed guinea pig spinal cords. We have analyzed regeneration of dorsal column axons in experimental animals and sham-treated controls at 50-60 days postinjury by anterograde filling of these axons with the intracellular marker horseradish peroxidase and by employing a marking device to identify precisely the original plane of transection (J. Comp. Neurol. 250: 157-167, '86). In response to electric field applications, axons grew into the glial scar, as far as the plane of transection in most experimental animals. In a few animals axons could be traced around the margins of the lesion (but never through it). Moreover, these fibers returned to their approximate positions within the rostral spinal cord before turning toward the brain. In sham-treated controls, ascending axons were found to terminate caudal to the glial scar, and rarely were any fibers found within the scar itself. Axons were never observed to cross into the rostral cord segment. These findings suggest that an imposed electrical field promotes growth of axons within the partially severed mammalian spinal cord, that a steady voltage gradient may be an environmental component necessary for axonal development and regeneration, and that some component(s) of the scar impede or deflect axonal growth and projection.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/3489013
Author(s): Seltzer Z, Cohn S, Ginzburg R, Beilin B
Author(s): Tseng AS, Beane WS, Lemire JM, Masi A, Levin M
Author(s): Ahmed Z, Wagdy M, Benjamin M, Mohamed S, Mohamed H, et al.
Author(s): Ahmed Z, Wieraszko A
Author(s): Debanne D, Poo MM
Author(s): Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, et al.
Author(s): Hanse E
Author(s): Triesch J
Author(s): Desai NS, Rutherford LC, Turrigiano GG
Author(s): Kennard JT, Guévremont D, Mason-Parker SE, Abraham WC, Williams JM
Author(s): Richter-Levin G, Canevari L, Bliss TV
Author(s): Clarkson AN, Overman JJ, Zhong S, Mueller R, Lynch G, et al.
Author(s): Chi SI, Levine JD, Basbaum AI
Author(s): Boroujerdi A, Kim HK, Lyu YS, Kim DS, Figueroa KW, et al.
Author(s): Cohn S, Seltzer Z
Author(s): Seltzer Z, Beilin BZ, Ginzburg R, Paran Y, Shimko T
Author(s): Ghijsen WE, Besselsen E, Geukers V, Kamphuis W, Lopes da Silva FH
Author(s): Bliss TV, Errington ML, Laroche S, Lynch MA
Author(s): Dolphin AC, Errington ML, Bliss TV
Author(s): Ahmed Z, Freedland R, Wieraszko A
Author(s): Ahmed Z
Author(s): Gruner JA
Author(s): Ahmed Z, Wieraszko A
Author(s): Jiang M, Schuster JE, Fu R, Siddique T, Heckman CJ
Author(s): Moghaddasi M, Velumian AA, Zhang L, Fehlings MG
Author(s): Jiang MC, Heckman CJ
Author(s): Sawynok J, Downie JW, Reid AR, Cahill CM, White TD
Author(s): Wieraszko A, Armani J, Maqsood N, Raja H, Philip S
Author(s): BROMAGE PR, JOYAL AC, BINNEY JC
Author(s): Foffani G, Humanes-Valera D, Calderon-Muñoz F, Oliviero A, Aguilar J
Author(s): Kuno M, Matsuura S
Author(s): McAdoo DJ, Hughes MG, Nie L, Shah B, Clifton C, et al.
Author(s): Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ
Author(s): Park E, Velumian AA, Fehlings MG
Author(s): Connelly TJ, Ahern C, Coronado R
Author(s): Kaye AD, Banister RE, Anwar M, Feng CJ, Kadowitz PJ, et al.
Author(s): Agrawal SK, Theriault E, Fehlings MG
Author(s): Lips J, de Haan P, Bodewits P, Vanicky I, Dzoljic M, et al.
Author(s): Gupta A, Devi LA, Gomes I
Author(s): Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, et al.
Author(s): Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, et al.
Author(s): Winkler T, Sharma HS, Stålberg E, Olsson Y, Nyberg F
Author(s): Bakshi R, Ni RX, Faden AI
Author(s): Chesler M, Sakatani K, Hassan AZ
Author(s): Katayama Y, Becker DP, Tamura T, Hovda DA
Author(s): Katayama Y, Kawamata T, Tamura T, Hovda DA, Becker DP, et al.
Author(s): Borgens RB
Author(s): Hamase K, Homma H, Takigawa Y, Fukushima T, Santa T, et al.
Author(s): Savage DD, Galindo R, Queen SA, Paxton LL, Allan AM
Author(s): Fleck MW, Barrionuevo G, Palmer AM
Author(s): Olsen ML, Campbell SC, McFerrin MB, Floyd CL, Sontheimer H
Author(s): Papke D, Gonzalez-Gutierrez G, Grosman C
Author(s): Sola E, Prestori F, Rossi P, Taglietti V, D'Angelo E
Author(s): Koyano K, Kuba K, Minota S
Author(s): Bliss TV, Douglas RM, Errington ML, Lynch MA
Author(s): Tsvetkov E, Shin RM, Bolshakov VY
Author(s): Levenson J, Weeber E, Selcher JC, Kategaya LS, Sweatt JD, et al.
Author(s): Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, et al.
Author(s): Williams JM, Guévremont D, Mason-Parker SE, Luxmanan C, Tate WP, et al.
Author(s): Malinow R
Author(s): Yang Y, Wang XB, Frerking M, Zhou Q
Author(s): Apaydin AZ, Büket S
Author(s): Kobrine AI, Evans DE, LeGrys DC, Yaffe LJ, Bradley ME
Author(s): Haghighi SS, Chehrazi BB, Higgins RS, Remington WJ, Wagner FC
Author(s): Robertson CS, Foltz R, Grossman RG, Goodman JC
Author(s): Hains BC, Saab CY, Lo AC, Waxman SG
Author(s): Schwartz G, Fehlings MG
Author(s): Waxman SG
Author(s): Borgens RB, Roederer E, Cohen MJ
Author(s): Borgens RB, Jaffe LF, Cohen MJ
Author(s): Obrenovitch TP, Urenjak J