Author(s): Papke D, Gonzalez-Gutierrez G, Grosman C
Changes in synaptic strength allow synapses to regulate the flow of information in the neural circuits in which they operate. In particular, changes lasting from milliseconds to minutes (‘short-term changes') underlie a variety of computational operations and, ultimately, behaviours. Most studies thus far have attributed the short-term type of plasticity to activity-dependent changes in the dynamics of neurotransmitter release (a presynaptic mechanism) while largely dismissing the role of the loss of responsiveness of postsynaptic receptor channels to neurotransmitter owing to entry into desensitization. To better define the response of the different neurotransmitter-gated ion channels (NGICs) to repetitive stimulation without interference from presynaptic variables, we studied eight representative members of all three known superfamilies of NGICs in fast-perfused outside-out patches of membrane. We found that the responsiveness of all tested channels (two nicotinic acetylcholine receptors, two glycine receptors, one GABA receptor, two AMPA-type glutamate receptors and one purinergic receptor) declines along trains of brief neurotransmitter pulses delivered at physiologically relevant frequencies to an extent that suggests that the role of desensitization in the synaptic control of action-potential transmission may be more general than previously thought. Furthermore, our results indicate that a sizable fraction (and, for some NGICs, most) of this desensitization occurs during the neurotransmitter-free interpulse intervals. Clearly, an incomplete clearance of neurotransmitter from the synaptic cleft between vesicle-fusion events need not be invoked to account for NGIC desensitization upon repetitive stimulation.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21300749
Author(s): Seltzer Z, Cohn S, Ginzburg R, Beilin B
Author(s): Tseng AS, Beane WS, Lemire JM, Masi A, Levin M
Author(s): Ahmed Z, Wagdy M, Benjamin M, Mohamed S, Mohamed H, et al.
Author(s): Ahmed Z, Wieraszko A
Author(s): Debanne D, Poo MM
Author(s): Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, et al.
Author(s): Hanse E
Author(s): Triesch J
Author(s): Desai NS, Rutherford LC, Turrigiano GG
Author(s): Kennard JT, Guévremont D, Mason-Parker SE, Abraham WC, Williams JM
Author(s): Richter-Levin G, Canevari L, Bliss TV
Author(s): Clarkson AN, Overman JJ, Zhong S, Mueller R, Lynch G, et al.
Author(s): Chi SI, Levine JD, Basbaum AI
Author(s): Boroujerdi A, Kim HK, Lyu YS, Kim DS, Figueroa KW, et al.
Author(s): Cohn S, Seltzer Z
Author(s): Seltzer Z, Beilin BZ, Ginzburg R, Paran Y, Shimko T
Author(s): Ghijsen WE, Besselsen E, Geukers V, Kamphuis W, Lopes da Silva FH
Author(s): Bliss TV, Errington ML, Laroche S, Lynch MA
Author(s): Dolphin AC, Errington ML, Bliss TV
Author(s): Ahmed Z, Freedland R, Wieraszko A
Author(s): Ahmed Z
Author(s): Gruner JA
Author(s): Ahmed Z, Wieraszko A
Author(s): Jiang M, Schuster JE, Fu R, Siddique T, Heckman CJ
Author(s): Moghaddasi M, Velumian AA, Zhang L, Fehlings MG
Author(s): Jiang MC, Heckman CJ
Author(s): Sawynok J, Downie JW, Reid AR, Cahill CM, White TD
Author(s): Wieraszko A, Armani J, Maqsood N, Raja H, Philip S
Author(s): BROMAGE PR, JOYAL AC, BINNEY JC
Author(s): Foffani G, Humanes-Valera D, Calderon-Muñoz F, Oliviero A, Aguilar J
Author(s): Kuno M, Matsuura S
Author(s): McAdoo DJ, Hughes MG, Nie L, Shah B, Clifton C, et al.
Author(s): Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ
Author(s): Park E, Velumian AA, Fehlings MG
Author(s): Connelly TJ, Ahern C, Coronado R
Author(s): Kaye AD, Banister RE, Anwar M, Feng CJ, Kadowitz PJ, et al.
Author(s): Agrawal SK, Theriault E, Fehlings MG
Author(s): Lips J, de Haan P, Bodewits P, Vanicky I, Dzoljic M, et al.
Author(s): Gupta A, Devi LA, Gomes I
Author(s): Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, et al.
Author(s): Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, et al.
Author(s): Winkler T, Sharma HS, Stålberg E, Olsson Y, Nyberg F
Author(s): Bakshi R, Ni RX, Faden AI
Author(s): Chesler M, Sakatani K, Hassan AZ
Author(s): Katayama Y, Becker DP, Tamura T, Hovda DA
Author(s): Katayama Y, Kawamata T, Tamura T, Hovda DA, Becker DP, et al.
Author(s): Borgens RB
Author(s): Hamase K, Homma H, Takigawa Y, Fukushima T, Santa T, et al.
Author(s): Savage DD, Galindo R, Queen SA, Paxton LL, Allan AM
Author(s): Fleck MW, Barrionuevo G, Palmer AM
Author(s): Olsen ML, Campbell SC, McFerrin MB, Floyd CL, Sontheimer H
Author(s): Sola E, Prestori F, Rossi P, Taglietti V, D'Angelo E
Author(s): Koyano K, Kuba K, Minota S
Author(s): Bliss TV, Douglas RM, Errington ML, Lynch MA
Author(s): Tsvetkov E, Shin RM, Bolshakov VY
Author(s): Levenson J, Weeber E, Selcher JC, Kategaya LS, Sweatt JD, et al.
Author(s): Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, et al.
Author(s): Williams JM, Guévremont D, Mason-Parker SE, Luxmanan C, Tate WP, et al.
Author(s): Malinow R
Author(s): Yang Y, Wang XB, Frerking M, Zhou Q
Author(s): Apaydin AZ, Büket S
Author(s): Kobrine AI, Evans DE, LeGrys DC, Yaffe LJ, Bradley ME
Author(s): Haghighi SS, Chehrazi BB, Higgins RS, Remington WJ, Wagner FC
Author(s): Robertson CS, Foltz R, Grossman RG, Goodman JC
Author(s): Hains BC, Saab CY, Lo AC, Waxman SG
Author(s): Schwartz G, Fehlings MG
Author(s): Waxman SG
Author(s): Borgens RB, Blight AR, Murphy DJ, Stewart L
Author(s): Borgens RB, Roederer E, Cohen MJ
Author(s): Borgens RB, Jaffe LF, Cohen MJ
Author(s): Obrenovitch TP, Urenjak J