Author(s): Kaye AD, Banister RE, Anwar M, Feng CJ, Kadowitz PJ, et al.
We studied the effects of ketamine in the isolated rat lung under conditions of increased pulmonary arterial pressure using the thromboxane A2 mimic, U46619, and in response to ventilatory hypoxia. Ketamine caused dose-dependent vasodilation, and possible mechanisms were evaluated using verapamil, meclofenamate, N(omega)-L-nitro-L-arginine benzyl ester (an inhibitor of nitric oxide synthase), and U-38883A (an ATP-sensitive potassium channel antagonist) in the isolated blood-perfused rat lung. Under increased tone conditions, N(omega)-L-nitro-L-arginine benzyl ester, meclofenamate, and U-38883A had no significant effect in attenuating ketamine-induced vasodilator responses. In a final series of experiments, verapamil significantly attenuated ketamine-induced vasodilator responses. These data suggest that ketamine has significant vasodilator activity in the pulmonary vascular bed of the rat, which seems to be mediated by an L-type calcium channel-sensitive pathway. These responses are not mediated or modulated by the release of nitric oxide, the activation of K+ ATP channels, or the release of vasodilator cyclooxygenase products.
Implications: In this study, we examined the mechanism of the vasodilator effects of ketamine in the blood-perfused rat lung. The results of the present study suggest that ketamine-induced vasodilator responses are mediated by an L-type calcium channel-sensitive pathway.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/9768801
Author(s): Seltzer Z, Cohn S, Ginzburg R, Beilin B
Author(s): Tseng AS, Beane WS, Lemire JM, Masi A, Levin M
Author(s): Ahmed Z, Wagdy M, Benjamin M, Mohamed S, Mohamed H, et al.
Author(s): Ahmed Z, Wieraszko A
Author(s): Debanne D, Poo MM
Author(s): Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, et al.
Author(s): Hanse E
Author(s): Triesch J
Author(s): Desai NS, Rutherford LC, Turrigiano GG
Author(s): Kennard JT, Guévremont D, Mason-Parker SE, Abraham WC, Williams JM
Author(s): Richter-Levin G, Canevari L, Bliss TV
Author(s): Clarkson AN, Overman JJ, Zhong S, Mueller R, Lynch G, et al.
Author(s): Chi SI, Levine JD, Basbaum AI
Author(s): Boroujerdi A, Kim HK, Lyu YS, Kim DS, Figueroa KW, et al.
Author(s): Cohn S, Seltzer Z
Author(s): Seltzer Z, Beilin BZ, Ginzburg R, Paran Y, Shimko T
Author(s): Ghijsen WE, Besselsen E, Geukers V, Kamphuis W, Lopes da Silva FH
Author(s): Bliss TV, Errington ML, Laroche S, Lynch MA
Author(s): Dolphin AC, Errington ML, Bliss TV
Author(s): Ahmed Z, Freedland R, Wieraszko A
Author(s): Ahmed Z
Author(s): Gruner JA
Author(s): Ahmed Z, Wieraszko A
Author(s): Jiang M, Schuster JE, Fu R, Siddique T, Heckman CJ
Author(s): Moghaddasi M, Velumian AA, Zhang L, Fehlings MG
Author(s): Jiang MC, Heckman CJ
Author(s): Sawynok J, Downie JW, Reid AR, Cahill CM, White TD
Author(s): Wieraszko A, Armani J, Maqsood N, Raja H, Philip S
Author(s): BROMAGE PR, JOYAL AC, BINNEY JC
Author(s): Foffani G, Humanes-Valera D, Calderon-Muñoz F, Oliviero A, Aguilar J
Author(s): Kuno M, Matsuura S
Author(s): McAdoo DJ, Hughes MG, Nie L, Shah B, Clifton C, et al.
Author(s): Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ
Author(s): Park E, Velumian AA, Fehlings MG
Author(s): Connelly TJ, Ahern C, Coronado R
Author(s): Agrawal SK, Theriault E, Fehlings MG
Author(s): Lips J, de Haan P, Bodewits P, Vanicky I, Dzoljic M, et al.
Author(s): Gupta A, Devi LA, Gomes I
Author(s): Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, et al.
Author(s): Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, et al.
Author(s): Winkler T, Sharma HS, Stålberg E, Olsson Y, Nyberg F
Author(s): Bakshi R, Ni RX, Faden AI
Author(s): Chesler M, Sakatani K, Hassan AZ
Author(s): Katayama Y, Becker DP, Tamura T, Hovda DA
Author(s): Katayama Y, Kawamata T, Tamura T, Hovda DA, Becker DP, et al.
Author(s): Borgens RB
Author(s): Hamase K, Homma H, Takigawa Y, Fukushima T, Santa T, et al.
Author(s): Savage DD, Galindo R, Queen SA, Paxton LL, Allan AM
Author(s): Fleck MW, Barrionuevo G, Palmer AM
Author(s): Olsen ML, Campbell SC, McFerrin MB, Floyd CL, Sontheimer H
Author(s): Papke D, Gonzalez-Gutierrez G, Grosman C
Author(s): Sola E, Prestori F, Rossi P, Taglietti V, D'Angelo E
Author(s): Koyano K, Kuba K, Minota S
Author(s): Bliss TV, Douglas RM, Errington ML, Lynch MA
Author(s): Tsvetkov E, Shin RM, Bolshakov VY
Author(s): Levenson J, Weeber E, Selcher JC, Kategaya LS, Sweatt JD, et al.
Author(s): Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, et al.
Author(s): Williams JM, Guévremont D, Mason-Parker SE, Luxmanan C, Tate WP, et al.
Author(s): Malinow R
Author(s): Yang Y, Wang XB, Frerking M, Zhou Q
Author(s): Apaydin AZ, Büket S
Author(s): Kobrine AI, Evans DE, LeGrys DC, Yaffe LJ, Bradley ME
Author(s): Haghighi SS, Chehrazi BB, Higgins RS, Remington WJ, Wagner FC
Author(s): Robertson CS, Foltz R, Grossman RG, Goodman JC
Author(s): Hains BC, Saab CY, Lo AC, Waxman SG
Author(s): Schwartz G, Fehlings MG
Author(s): Waxman SG
Author(s): Borgens RB, Blight AR, Murphy DJ, Stewart L
Author(s): Borgens RB, Roederer E, Cohen MJ
Author(s): Borgens RB, Jaffe LF, Cohen MJ
Author(s): Obrenovitch TP, Urenjak J