Author(s): Tseng AS, Beane WS, Lemire JM, Masi A, Levin M
Amphibians such as frogs can restore lost organs during development, including the lens and tail. To design biomedical therapies for organ repair, it is necessary to develop a detailed understanding of natural regeneration. Recently, ion transport has been implicated as a functional regulator of regeneration. Whereas voltage-gated sodium channels play a well known and important role in propagating action potentials in excitable cells, we have identified a novel role in regeneration for the ion transport function mediated by the voltage-gated sodium channel, Na(V)1.2. A local, early increase in intracellular sodium is required for initiating regeneration following Xenopus laevis tail amputation, and molecular and pharmacological inhibition of sodium transport causes regenerative failure. Na(V)1.2 is absent under nonregenerative conditions, but misexpression of human Na(V)1.5 can rescue regeneration during these states. Remarkably, pharmacological induction of a transient sodium current is capable of restoring regeneration even after the formation of a nonregenerative wound epithelium, confirming that it is the regulation of sodium transport that is critical for regeneration. Our studies reveal a previously undetected competency window in which cells retain their intrinsic regenerative program, identify a novel endogenous role for Na(V) in regeneration, and show that modulation of sodium transport represents an exciting new approach to organ repair.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20881138
Author(s): Seltzer Z, Cohn S, Ginzburg R, Beilin B
Author(s): Ahmed Z, Wagdy M, Benjamin M, Mohamed S, Mohamed H, et al.
Author(s): Ahmed Z, Wieraszko A
Author(s): Debanne D, Poo MM
Author(s): Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, et al.
Author(s): Hanse E
Author(s): Triesch J
Author(s): Desai NS, Rutherford LC, Turrigiano GG
Author(s): Kennard JT, Guévremont D, Mason-Parker SE, Abraham WC, Williams JM
Author(s): Richter-Levin G, Canevari L, Bliss TV
Author(s): Clarkson AN, Overman JJ, Zhong S, Mueller R, Lynch G, et al.
Author(s): Chi SI, Levine JD, Basbaum AI
Author(s): Boroujerdi A, Kim HK, Lyu YS, Kim DS, Figueroa KW, et al.
Author(s): Cohn S, Seltzer Z
Author(s): Seltzer Z, Beilin BZ, Ginzburg R, Paran Y, Shimko T
Author(s): Ghijsen WE, Besselsen E, Geukers V, Kamphuis W, Lopes da Silva FH
Author(s): Bliss TV, Errington ML, Laroche S, Lynch MA
Author(s): Dolphin AC, Errington ML, Bliss TV
Author(s): Ahmed Z, Freedland R, Wieraszko A
Author(s): Ahmed Z
Author(s): Gruner JA
Author(s): Ahmed Z, Wieraszko A
Author(s): Jiang M, Schuster JE, Fu R, Siddique T, Heckman CJ
Author(s): Moghaddasi M, Velumian AA, Zhang L, Fehlings MG
Author(s): Jiang MC, Heckman CJ
Author(s): Sawynok J, Downie JW, Reid AR, Cahill CM, White TD
Author(s): Wieraszko A, Armani J, Maqsood N, Raja H, Philip S
Author(s): BROMAGE PR, JOYAL AC, BINNEY JC
Author(s): Foffani G, Humanes-Valera D, Calderon-Muñoz F, Oliviero A, Aguilar J
Author(s): Kuno M, Matsuura S
Author(s): McAdoo DJ, Hughes MG, Nie L, Shah B, Clifton C, et al.
Author(s): Xu GY, Hughes MG, Ye Z, Hulsebosch CE, McAdoo DJ
Author(s): Park E, Velumian AA, Fehlings MG
Author(s): Connelly TJ, Ahern C, Coronado R
Author(s): Kaye AD, Banister RE, Anwar M, Feng CJ, Kadowitz PJ, et al.
Author(s): Agrawal SK, Theriault E, Fehlings MG
Author(s): Lips J, de Haan P, Bodewits P, Vanicky I, Dzoljic M, et al.
Author(s): Gupta A, Devi LA, Gomes I
Author(s): Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, et al.
Author(s): Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, et al.
Author(s): Winkler T, Sharma HS, Stålberg E, Olsson Y, Nyberg F
Author(s): Bakshi R, Ni RX, Faden AI
Author(s): Chesler M, Sakatani K, Hassan AZ
Author(s): Katayama Y, Becker DP, Tamura T, Hovda DA
Author(s): Katayama Y, Kawamata T, Tamura T, Hovda DA, Becker DP, et al.
Author(s): Borgens RB
Author(s): Hamase K, Homma H, Takigawa Y, Fukushima T, Santa T, et al.
Author(s): Savage DD, Galindo R, Queen SA, Paxton LL, Allan AM
Author(s): Fleck MW, Barrionuevo G, Palmer AM
Author(s): Olsen ML, Campbell SC, McFerrin MB, Floyd CL, Sontheimer H
Author(s): Papke D, Gonzalez-Gutierrez G, Grosman C
Author(s): Sola E, Prestori F, Rossi P, Taglietti V, D'Angelo E
Author(s): Koyano K, Kuba K, Minota S
Author(s): Bliss TV, Douglas RM, Errington ML, Lynch MA
Author(s): Tsvetkov E, Shin RM, Bolshakov VY
Author(s): Levenson J, Weeber E, Selcher JC, Kategaya LS, Sweatt JD, et al.
Author(s): Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, et al.
Author(s): Williams JM, Guévremont D, Mason-Parker SE, Luxmanan C, Tate WP, et al.
Author(s): Malinow R
Author(s): Yang Y, Wang XB, Frerking M, Zhou Q
Author(s): Apaydin AZ, Büket S
Author(s): Kobrine AI, Evans DE, LeGrys DC, Yaffe LJ, Bradley ME
Author(s): Haghighi SS, Chehrazi BB, Higgins RS, Remington WJ, Wagner FC
Author(s): Robertson CS, Foltz R, Grossman RG, Goodman JC
Author(s): Hains BC, Saab CY, Lo AC, Waxman SG
Author(s): Schwartz G, Fehlings MG
Author(s): Waxman SG
Author(s): Borgens RB, Blight AR, Murphy DJ, Stewart L
Author(s): Borgens RB, Roederer E, Cohen MJ
Author(s): Borgens RB, Jaffe LF, Cohen MJ
Author(s): Obrenovitch TP, Urenjak J