Author(s): Xiong XY, Li YP, Li ZL, Zhou CL, Tam KC, et al.
The morphologies of poly(lactic acid)-b-Pluronic-b-poly(lactic acid) (PLA-F127-PLA) aggregates in aqueous solutions were reported previously to be vesicular nano-particles by our group. In the present study, we seek to investigate the feasibility of using PLA-F127-PLA vesicles as oral delivery carrier for insulin. Both in vitro and in vivo release behavior of insulin loaded in PLA-F127-PLA vesicles were studied. A biphasic release behavior was observed for the in vitro release of insulin from PLAF127-29 vesicles. More importantly, it was found in the diabetic mice tests that the blood glucose concentration of oral insulin-loaded PLAF127-29 vesicles decreased from 18.5 to 5.3 mmol/L within 4.5 h and the minimum blood glucose concentration (about 4.5 mmol/L) was achieved after about 5 h. Furthermore, the blood glucose concentration was maintained at this level for at least an additional 18.5 h. These results proved that PLA-F127-PLA vesicles could be promising polymeric carriers for oral insulin delivery application due to their prolonged hypoglycemic effect.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17509718
Author(s): Beals J, Brader M, De Felippis M, Kovach P
Author(s): American Diabetes Association
Author(s): Fonte P, Araújo F, Reis S, Sarmento B
Author(s): Rosenfeld L
Author(s): Al-Tabakha MM, Arida AL
Author(s): Bhatia E, Aggarwal A
Author(s): Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM
Author(s): Magwire ML
Author(s): Arbit E, Kidron M
Author(s): Varshosaz J
Author(s): Heinemann L, Jacques Y
Author(s): Eldor R, Arbit E, Schurr D, Kidron M, Hersko A
Author(s): Gu Z, Aimetti AA, Wang Q, Dang TT, Zhang Y, et al.
Author(s): Trapani A, Lopedota A, Franco M, Cioffi N, Ieva E, et al.
Author(s): Cui F, Qian F, Zhao Z, Yin L, Tang C, et al.
Author(s): Li T, Shi XW, Du YM, Tang YF
Author(s): Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, et al.
Author(s): Ma Z, Yeoh HH, Lim LY
Author(s): Zhang N, Ping Q, Huang G, Xu W, Cheng Y, et al.
Author(s): Chen MC, Sonaje K, Chen KJ, Sung HW
Author(s): Babu VR, Patel P, Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Damgé C, Reis CP, Maincent P
Author(s): des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V
Author(s): Michel C, Aprahamian M, Defontaine L, Couvreur P, Damgé C
Author(s): Damgé C, Michel C, Aprahamian M, Couvreur P
Author(s): Sajeesh S, Sharma CP
Author(s): Carino GP, Jacob JS, Mathiowitz E
Author(s): Jose S, Fangueiro JF, Smitha J, Cinu TA, Chacko AJ, et al.
Author(s): Chaudhury A, Das S
Author(s): Niu M, Lua Y, Hovgaard L, Guan P, Tan Y, et al.
Author(s): Sarmento B, Martins S, Ferreira D, Souto EB
Author(s): Elsayed AM
Author(s): Sung HW, Sonaje K, Feng SS
Author(s): Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK
Author(s): Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MH, et al.
Author(s): Ramachandran R, Paul W, Sharma CP
Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Najafzadeh H, Kooshapur H, Kianidehkordi F
Author(s): Sung HW, Sonaje K, Liao ZX, Hsu LW, Chuang EY
Author(s): Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, et al.
Author(s): Sabetsky V, Ekblom J
Author(s): Castor TP
