Author(s): Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM
The search for an effective and reliable oral insulin delivery system has been a major challenge facing pharmaceutical scientists for over many decades. Even though innumerable carrier systems that protect insulin from degradation in the GIT with improved membrane permeability and biological activity have been developed, yet a clinically acceptable device is not available for human application. Efforts in this direction are continuing at an accelerated speed. One of the preferred systems widely explored is based on polymeric hydrogels that protect insulin from enzymatic degradation in acidic stomach and delivers effectively in the intestine. Swelling and deswelling mechanisms of the hydrogel under varying pH conditions of the body control the release of insulin. The micro and nanoparticle (NP) hydrogel devices based on biopolymers have been widely explored, but their applications in human insulin therapy are still far from satisfactory. The present review highlights the recent findings on hydrogel-based devices for oral delivery of insulin. Literature data are critically assessed and results from different laboratories are compared.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/23159827
Author(s): Beals J, Brader M, De Felippis M, Kovach P
Author(s): American Diabetes Association
Author(s): Fonte P, Araújo F, Reis S, Sarmento B
Author(s): Rosenfeld L
Author(s): Al-Tabakha MM, Arida AL
Author(s): Bhatia E, Aggarwal A
Author(s): Magwire ML
Author(s): Arbit E, Kidron M
Author(s): Varshosaz J
Author(s): Heinemann L, Jacques Y
Author(s): Eldor R, Arbit E, Schurr D, Kidron M, Hersko A
Author(s): Gu Z, Aimetti AA, Wang Q, Dang TT, Zhang Y, et al.
Author(s): Trapani A, Lopedota A, Franco M, Cioffi N, Ieva E, et al.
Author(s): Cui F, Qian F, Zhao Z, Yin L, Tang C, et al.
Author(s): Li T, Shi XW, Du YM, Tang YF
Author(s): Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, et al.
Author(s): Ma Z, Yeoh HH, Lim LY
Author(s): Zhang N, Ping Q, Huang G, Xu W, Cheng Y, et al.
Author(s): Chen MC, Sonaje K, Chen KJ, Sung HW
Author(s): Babu VR, Patel P, Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Damgé C, Reis CP, Maincent P
Author(s): des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V
Author(s): Michel C, Aprahamian M, Defontaine L, Couvreur P, Damgé C
Author(s): Damgé C, Michel C, Aprahamian M, Couvreur P
Author(s): Sajeesh S, Sharma CP
Author(s): Carino GP, Jacob JS, Mathiowitz E
Author(s): Jose S, Fangueiro JF, Smitha J, Cinu TA, Chacko AJ, et al.
Author(s): Chaudhury A, Das S
Author(s): Niu M, Lua Y, Hovgaard L, Guan P, Tan Y, et al.
Author(s): Xiong XY, Li YP, Li ZL, Zhou CL, Tam KC, et al.
Author(s): Sarmento B, Martins S, Ferreira D, Souto EB
Author(s): Elsayed AM
Author(s): Sung HW, Sonaje K, Feng SS
Author(s): Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK
Author(s): Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MH, et al.
Author(s): Ramachandran R, Paul W, Sharma CP
Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Najafzadeh H, Kooshapur H, Kianidehkordi F
Author(s): Sung HW, Sonaje K, Liao ZX, Hsu LW, Chuang EY
Author(s): Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, et al.
Author(s): Sabetsky V, Ekblom J
Author(s): Castor TP