Nanomedicine for diabetes treatment

Author(s): Sung HW, Sonaje K, Feng SS

Abstract

Diabetes (diabetes mellitus) is a metabolic disorder which results in high levels of blood glucose. It can be classified as either Type 1 or Type 2, depending on the reason for the high glucose levels. Type 1 diabetes means that the pancreas cannot produce insulin (a hormone which enables the uptake of glucose by the liver, muscle and fat tissue), whereas Type 2 means that the body's cells do not respond to the presence of insulin.

Whilst Type 1 diabetes can be fatal if untreated, most patients today survive into old age - however, they must inject insulin several times a day to allow their body to use the glucose from their food.

Our understanding and ability to treat insulin has been improving steadily, ever since the first insulin injections were carried out in the early 1920s by Banting and Best. Despite all the advances which have been made, insulin cannot be cured altogether, and a good deal of research effort is aimed at improving quality of life for diabetic patients, making their glucose tests and insulin injections as easy and non-invasive as possible, and potentially devising a permanent cure for diabetes.

Similar Articles

Insulin

Author(s): Beals J, Brader M, De Felippis M, Kovach P

Diagnosis and Classification of Diabetes Mellitus

Author(s): American Diabetes Association

Oral insulin delivery: how far are we? J Diabetes Sci Technol 7: 520-531

Author(s): Fonte P, Araújo F, Reis S, Sarmento B

Insulin: discovery and controversy

Author(s): Rosenfeld L

Polymeric hydrogels for oral insulin delivery

Author(s): Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM

Dose response to oral insulin capsules in fasting, healthy subjects

Author(s): Eldor R, Arbit E, Schurr D, Kidron M, Hersko A

Injectable nano-network for glucose-mediated insulin delivery

Author(s): Gu Z, Aimetti AA, Wang Q, Dang TT, Zhang Y, et al.

Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin

Author(s): Zhang N, Ping Q, Huang G, Xu W, Cheng Y, et al.

Developments in polymeric devices for oral insulin delivery

Author(s): Babu VR, Patel P, Mundargi RC, Rangaswamy V, Aminabhavi TM

Nanoparticle strategies for the oral delivery of insulin

Author(s): Damgé C, Reis CP, Maincent P

Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach

Author(s): des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V

Nanosphere based oral insulin delivery

Author(s): Carino GP, Jacob JS, Mathiowitz E

Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing

Author(s): Jose S, Fangueiro JF, Smitha J, Cinu TA, Chacko AJ, et al.

Oral insulin delivery by means of solid lipid nanoparticles

Author(s): Sarmento B, Martins S, Ferreira D, Souto EB

Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles

Author(s): Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK

Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery

Author(s): Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MH, et al.

pH-Sensitive oral insulin delivery systems using Eudragit microspheres

Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM

Evaluation of an oral insulin formulation in normal and diabetic rats

Author(s): Najafzadeh H, Kooshapur H, Kianidehkordi F

Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery

Author(s): Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, et al.

Insulin: A new era for an old hormone

Author(s): Sabetsky V, Ekblom J