Author(s): Varshosaz J
The goal of all drug delivery systems is to deploy medications intact to specifically targeted parts of the body through a medium that can control the therapys administration by means of either a physiological or chemical trigger. The polypeptide insulin is the primary hormone responsible for controlling the transport, utilization and storage of glucose in the body. Due to the inconvenience of insulin injections, various approaches have been attempted to formulate insulin for administration by non-injectable routes. Different approaches to deliver insulin including transdermal, transmucosal, pulmonary route using dry aerosols and inhalers, smart hydrogels, nasal delivery, oral delivery, and treatment of diabetes with synthetic beta cells, has resulted in recent developments in treatment of diabetes. Among the latest patent approaches are delivering into the subject a genetic construct comprising a coding sequence for a human proinsulin operably connected a promoter functional in the host cells. Polypeptides having activity of human neurogenin3 (hNgn3), and nucleic acid encoding such polypeptide are among the other inventions that use of islet transcription factors such as hNgn3 to facilitate production of pancreatic islet cells from progenitor cells, and to facilitate insulin delivery by production of islet cells so produced.
Referred From: http://www.eurekaselect.com/article/34822
Author(s): Beals J, Brader M, De Felippis M, Kovach P
Author(s): American Diabetes Association
Author(s): Fonte P, Araújo F, Reis S, Sarmento B
Author(s): Rosenfeld L
Author(s): Al-Tabakha MM, Arida AL
Author(s): Bhatia E, Aggarwal A
Author(s): Chaturvedi K, Ganguly K, Nadagouda MN, Aminabhavi TM
Author(s): Magwire ML
Author(s): Arbit E, Kidron M
Author(s): Heinemann L, Jacques Y
Author(s): Eldor R, Arbit E, Schurr D, Kidron M, Hersko A
Author(s): Gu Z, Aimetti AA, Wang Q, Dang TT, Zhang Y, et al.
Author(s): Trapani A, Lopedota A, Franco M, Cioffi N, Ieva E, et al.
Author(s): Cui F, Qian F, Zhao Z, Yin L, Tang C, et al.
Author(s): Li T, Shi XW, Du YM, Tang YF
Author(s): Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, et al.
Author(s): Ma Z, Yeoh HH, Lim LY
Author(s): Zhang N, Ping Q, Huang G, Xu W, Cheng Y, et al.
Author(s): Chen MC, Sonaje K, Chen KJ, Sung HW
Author(s): Babu VR, Patel P, Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Damgé C, Reis CP, Maincent P
Author(s): des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V
Author(s): Michel C, Aprahamian M, Defontaine L, Couvreur P, Damgé C
Author(s): Damgé C, Michel C, Aprahamian M, Couvreur P
Author(s): Sajeesh S, Sharma CP
Author(s): Carino GP, Jacob JS, Mathiowitz E
Author(s): Jose S, Fangueiro JF, Smitha J, Cinu TA, Chacko AJ, et al.
Author(s): Chaudhury A, Das S
Author(s): Niu M, Lua Y, Hovgaard L, Guan P, Tan Y, et al.
Author(s): Xiong XY, Li YP, Li ZL, Zhou CL, Tam KC, et al.
Author(s): Sarmento B, Martins S, Ferreira D, Souto EB
Author(s): Elsayed AM
Author(s): Sung HW, Sonaje K, Feng SS
Author(s): Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK
Author(s): Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MH, et al.
Author(s): Ramachandran R, Paul W, Sharma CP
Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Mundargi RC, Rangaswamy V, Aminabhavi TM
Author(s): Najafzadeh H, Kooshapur H, Kianidehkordi F
Author(s): Sung HW, Sonaje K, Liao ZX, Hsu LW, Chuang EY
Author(s): Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, et al.
Author(s): Sabetsky V, Ekblom J
Author(s): Castor TP