Author(s): Filbey FM, Claus E, Audette AR, Niculescu M, Banich MT, et al.
A growing number of imaging studies suggest that alcohol cues, mainly visual, elicit activation in mesocorticolimbic structures. Such findings are consistent with the growing recognition that these structures play an important role in the attribution of incentive salience and the pathophysiology of addiction. The present study investigated whether the presentation of alcohol taste cues can activate brain regions putatively involved in the acquisition and expression of incentive salience. Using functional magnetic resonance imaging, we recorded BOLD activity while delivering alcoholic tastes to 37 heavy drinking but otherwise healthy volunteers. The results yielded a pattern of BOLD activity in mesocorticolimbic structures (ie prefrontal cortex, striatum, ventral tegmental area/substantia nigra) relative to an appetitive control. Further analyses suggested strong connectivity between these structures during cue-elicited urge and demonstrated significant positive correlations with a measure of alcohol use problems (ie the Alcohol Use Disorders Identification Test). Thus, repeated exposure to the taste alcohol in the scanner elicits activation in mesocorticolimbic structures, and this activation is related to measures of urge and severity of alcohol problems.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17653109
Author(s): Palfai TP, Monti PM, Ostafin B, Hutchison K
Author(s): Harrison EL, Hinson RE, McKee SA
Author(s): Howell A, Leyro T, Hogan J, Buckner J, Zvolensky M
Author(s): Krukowski RA, Solomon LJ, Naud S
Author(s): Reed MB, Wang R, Shillington AM, Clapp JD, Lange JE
Author(s): Hughes JR, Kalman D
Author(s): Hurt RD, Offord KP, Croghan IT, Gomez-Dahl L, Kottke TE, et al.
Author(s): Lisha NE, Carmody TP2, Humfleet GL2, Delucchi KL2
Author(s): Taylor B, Rehm J
Author(s): Jarvis CM, Hayman LL, Braun LT, Schwertz DW, Ferrans CE, et al.
Author(s): Joseph AM, Willenbring ML, Nugent SM, Nelson DB
Author(s): Kodl M, Fu SS, Joseph AM
Author(s): Fu S, Kodl M, Willenbring M, Nelson D, Nugent S, et al.
Author(s): Holt LJ, Litt MD, Cooney NL
Author(s): Centers for Disease Control and Prevention (CDC)
Author(s): Irving LM, Seidner AL, Burling TA, Thomas RG, Brenner GF
Author(s): Macnee CL, Talsma A
Author(s): Orleans CT, Rimer BK, Cristinzio S, Keintz MK, Fleisher L
Author(s): Asher MK, Martin RA, Rohsenow DJ, MacKinnon S, Traficante R, et al.
Author(s): Martin RA, Rohsenow DJ, MacKinnon SV, Abrams DB, Monti PM
Author(s): Velicer WF, DiClemente CC, Prochaska JO, Brandenburg N
Author(s): DiClemente CC, Prochaska JO
Author(s): Curry SJ, Grothaus L, McBride C
Author(s): Baha M, Le Faou AL
Author(s): Curry SJ, McBride C, Grothaus LC, Louie D, Wagner EH
Author(s): Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M
Author(s): Brown RA, Lejuez CW, Kahler CW, Strong DR
Author(s): Heatherton TF, Kozlowski LT, Frecker RC, FagerstrÃ¶m KO
Author(s): Pomerleau CS, Carton SM, Lutzke ML, Flessland KA, Pomerleau OF
Author(s): Fleming MF, Barry KL, MacDonald R
Author(s): Cherpitel CJ
Author(s): Macnee CL, Talsma A
Author(s): Curry S, Wagner EH, Grothaus LC
Author(s): McBride CM, Pollak KI, Bepler G, Lyna P, Lipkus IM, et al.
Author(s): Bonn-Miller MO, Zvolensky MJ
Author(s): Buckner JD, Zvolensky MJ, Schmidt NB
Author(s): Agrawal A, Budney AJ, Lynskey MT
Author(s): Degenhardt L, Hall W, Lynskey M
Author(s): Wilson SJ, Creswell KG, Sayette MA, Fiez JA
Author(s): Schane RE, Glantz SA, Ling PM
Author(s): DaniJA, De Biasi M
Author(s): Nestler EJ
Author(s): Ehrman RN, Robbins SJ, Bromwell MA, Lankford ME, Monterosso JR, et al.
Author(s): Wiers RW, Rinck M, Kordts R, Houben K, Strack F
Author(s): Korte KJ, Capron DW, Zvolensky M, Schmidt NB