Author(s): Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, et al.
Gβγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with respect to signaling, often independently as well as in concert with Gα subunits. However, the eponymous term “Gβγ” does not do justice to the fact that 5 Gβ and 12 Gγ isoforms have evolved in mammals to serve much broader roles beyond their canonical roles in cellular signaling. We explore the phylogenetic diversity of Gβγ subunits with a view toward understanding these expanded roles in different cellular organelles. We suggest that the particular content of distinct Gβγ subunits regulates cellular activity, and that the granularity of individual Gβ and Gγ action is only beginning to be understood. Given the therapeutic potential of targeting Gβγ action, this larger view serves as a prelude to more specific development of drugs aimed at individual isoforms.
Referred From: http://pharmrev.aspetjournals.org/content/65/2/545
Author(s): Murphy MP, LeVine H
Author(s): Kalaria RN, Andorn AC, Tabaton M, Whitehouse PJ, Harik SI, et al.
Author(s): Yu JT, Tan L, Ou JR, Zhu JX, Liu K, et al.
Author(s): Ni Y, Zhao X, Bao G, Zou L, Teng L, et al.
Author(s): Wang D, Fu Q, Zhou Y, Xu B, Shi Q, et al.
Author(s): Wisely EV, Xiang YK, Oddo S3
Author(s): Gelber RP, Ross GW, Petrovitch H, Masaki KH, Launer LJ, et al.
Author(s): White LR, Gelber RP, Launer LJ, Zarow C, Sonnen J, et al.
Author(s): Gelber RP, Ross GW, Petrovitch H, Masaki KH, Launer LJ, et al.
Author(s): Dupre DJ, Herbert TE, Jockers R
Author(s): Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK
Author(s): Gloerich M, Bos JL
Author(s): Clapham DE, Neer EJ
Author(s): Wickman KD, Iniguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, et al.
Author(s): Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, et al.
Author(s): Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, et al.
Author(s): Oakley H, Cole SL, Logan S, Maus E, Shao P, et al.
Author(s): Storey JD, Tibshirani R
Author(s): Burns A, Iliffe S
Author(s): Kawas CH
Author(s): Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, et al.
Author(s): Yankner BA, Duffy LK, Kirschner DA
Author(s): Lesne SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, et al.
Author(s): Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, et al.
Author(s): Wang D, Xiang YK
Author(s): Luong K, Nguyen LT
Author(s): Ross JA, McGonigle P1, Van Bockstaele EJ
Author(s): Storey JD, Tibshirani R
Author(s): Münz C
Author(s): Aderem A, Underhill DM