Author(s): Storey JD, Tibshirani R
With the increase in genomewide experiments and the sequencing of multiple genomes, the analysis of large data sets has become commonplace in biology. It is often the case that thousands of features in a genomewide data set are tested against some null hypothesis, where a number of features are expected to be significant. Here we propose an approach to measuring statistical significance in these genomewide studies based on the concept of the false discovery rate. This approach offers a sensible balance between the number of true and false positives that is automatically calibrated and easily interpreted. In doing so, a measure of statistical significance called the q value is associated with each tested feature. The q value is similar to the well known p value, except it is a measure of significance in terms of the false discovery rate rather than the false positive rate. Our approach avoids a flood of false positive results, while offering a more liberal criterion than what has been used in genome scans for linkage.
Referred From: http://www.pnas.org/content/100/16/9440
Author(s): Murphy MP, LeVine H
Author(s): Kalaria RN, Andorn AC, Tabaton M, Whitehouse PJ, Harik SI, et al.
Author(s): Yu JT, Tan L, Ou JR, Zhu JX, Liu K, et al.
Author(s): Ni Y, Zhao X, Bao G, Zou L, Teng L, et al.
Author(s): Wang D, Fu Q, Zhou Y, Xu B, Shi Q, et al.
Author(s): Wisely EV, Xiang YK, Oddo S3
Author(s): Gelber RP, Ross GW, Petrovitch H, Masaki KH, Launer LJ, et al.
Author(s): White LR, Gelber RP, Launer LJ, Zarow C, Sonnen J, et al.
Author(s): Gelber RP, Ross GW, Petrovitch H, Masaki KH, Launer LJ, et al.
Author(s): Dupre DJ, Herbert TE, Jockers R
Author(s): Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK
Author(s): Gloerich M, Bos JL
Author(s): Clapham DE, Neer EJ
Author(s): Wickman KD, Iniguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, et al.
Author(s): Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, et al.
Author(s): Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, et al.
Author(s): Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, et al.
Author(s): Oakley H, Cole SL, Logan S, Maus E, Shao P, et al.
Author(s): Storey JD, Tibshirani R
Author(s): Burns A, Iliffe S
Author(s): Kawas CH
Author(s): Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, et al.
Author(s): Yankner BA, Duffy LK, Kirschner DA
Author(s): Lesne SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, et al.
Author(s): Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, et al.
Author(s): Wang D, Xiang YK
Author(s): Luong K, Nguyen LT
Author(s): Ross JA, McGonigle P1, Van Bockstaele EJ
Author(s): Münz C
Author(s): Aderem A, Underhill DM