Author(s): Takeuchi H, Yasuji T, Yamamoto H, Kawashima Y
Purpose: The properties of novel spray-dried lactose composite particles suitable for the coating filler of a dry-coated tablet having a long induction period in drug release were investigated.
Methods: To prepare spray-dried composite particles containing alginate-chitosan complex (SD(L/AL-CS)), an aqueous solution of lactose and sodium alginate and the acetic acid solution of chitosan were concomitantly fed into the rotary atomizer of a spray-dryer. The formation of the alginate-chitosan complex was confirmed by measuring the weight of insoluble portion in the mixture of sodium alginate and chitosan solutions. The dissolution properties of the dry-coated tablet were measured with the JP specified paddle method.
Results: The micromeritic properties of SD(L/AL-CS) were compared to those of the SD composite particles of lactose-sodium alginate, having a good compacting property. The drug release profiles of dry-coated tablet with SD(L/AL-CS) contained a long induction period followed by a rapid drug release phase in the artificial intestinal fluid. The induction period for drug release to occur was increased with an increase in the degree of deacetylation of chitosan and in the amount of chitosan in the formulation. The prolongation of induction period was attributed to the formation of an insoluble ion complex between sodium alginate and chitosan in the composite particles, which could form a rigid gel structure on the tablet surface.
Conclusions: A time-controlled release tablet was designed with the composite particles of lactose containing the alginate-chitosan ion complex. The induction period of the dry-coated tablet could be prolonged in order to deliver the drug to the colon by controlling the type and amount of chitosan formulated in the composite particles.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10714615
Author(s): Siepmann J, Peppas NA
Author(s): Miller AD, Mcginity JW
Author(s): Tondachi M, Hoshi N, Sekigawa F
Author(s): Hogan JE
Author(s): Suzzi D, Radi S, Khinast JG
Author(s): Cole G, Aulton ME, Hogan J
Author(s): Hogan JE
Author(s): Martins E, Christiana I, Olobayo K
Author(s): Muazu J, Musa H, Musa KY
Author(s): Okafor IS, Danat IM
Author(s): Ogaji IJ, Hoag SW
Author(s): Nep EI, Conway BR
Author(s): Ogaji IJ, Okafor IS, Hoag SW
Author(s): Ogaji IJ, Okafor IS, Hoag SW
Author(s): Ogaji I, Okafor IS
Author(s): Bayraktar O, Malay O, Ozgarip Y, Batigün A
Author(s): Fassihi AR, Munday DL
Author(s): Kirsch JD, Drennen JK
Author(s): Lin WJ, Lee HG
Author(s): McGinity JW, Cameron CG, Cuff GW
Author(s): Weinberger M, Hendeles L, Bighley L
Author(s): Pandey P, Katakdaunde M, Turton R
Author(s): Pandey P, Song Y, Turton R
Author(s): Pandey P, Turton R
Author(s): Pandey P, Song Y, Kayihan F, Turton R
Author(s): Lowenthal W
Author(s): Banker GS, Anderson NR
Author(s): Lowenthal W
Author(s): Osborn BG, Fearn T, Hindle PH
Author(s): Jamil N, Ahmad I
Author(s): Duvall RN, Koshy KT, Dashiell RE
Author(s): Lee S, Dekay HG, Banker GS