Mechanism of action of starch as a tablet disintegrant

Author(s): Lowenthal W

Abstract

Corn and waxy maise starches were observed under a light microscope and a scanning electron microscope. The effects of pressure and moisture were studied in both individual grains and in tablets. The starch grains were deformed by pressure and did not regain their original shape when moistened, nor was there significant swelling. The deformed cornstarch grains appeared to retain their birefringence. The regaining of the shape of starch grains is apparently not the mechanism of action as a tablet disintegrant.

 

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