Author(s): Safaeian M, Kiddugavu M, Gravitt PE, Ssekasanvu J, Murokora D, et al.
Objective: The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda.
Study design: Between 2002 and 2003, women from a population-based cohort participated in an HPV study. Women collected self-administered vaginal swabs and were also offered a pelvic examination, which included physician-collected cervical samples.
Methods: Hybrid-capture 2 was used to determine carcinogenic HPV status. Polymerase chain reaction was used to determine HPV genotypes. Unweighted kappa statistics were used to determine agreement.
Results: Compliance with self-collected swabs was > or =86%; however, only 51% accepted a pelvic examination. Carcinogenic HPV prevalence was 19% in self-collected and 19% in physician-collected samples. Agreement among paired observations was 92% with a kappa of 0.75. Kappa between self- and physician-collected samples was similar in HIV strata (k = 0.71 and 0.75 for HIV-positive and HIV-negative, respectively).
Discussion: In this community-based setting, detection of carcinogenic HPV was comparable among self- and physician-administered samples. Self-collection is a feasible and accurate means of obtaining HPV samples from women in resource-poor settings or persons reluctant to undergo a pelvic examination.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17075437
Author(s): Lack N, West B, Jeffries D, Ekpo G, Morison L, et al.
Author(s): Jones HE, Wiegerinck MA, Nieboer TE, Mol BW, Westhoff CL
Author(s): Deleré Y, Schuster M, Vartazarowa E, Hänsel T, Hagemann I, et al.
Author(s): Petignat P, Faltin DL, Bruchim I, Tramèr MR, Franco EL, et al.
Author(s): Mollers M, Scherpenisse M, van der Klis FR, King AJ, van Rossum TG, et al.
Author(s): Chranioti A, Aga E, Margari N, Kottaridi C, Pappas A, et al.
Author(s): Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, et al.
Author(s): Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, et al.
Author(s): Petignat P, Hankins C, Walmsley S, Money D, Provencher D, et al.
Author(s): Jones HE, Allan BR, van de Wijgert JH, Altini L, Taylor SM, et al.
Author(s): Kahn JA, Slap GB, Huang B, Rosenthal SL, Wanchick AM, et al.
Author(s): Karwalajtys T, Howard M, Sellors JW, Kaczorowski J
Author(s): Agorastos T, Dinas K, Lloveras B, Font R, Kornegay JR, et al.
Author(s): Baldwin S, Santos C, Mendez Brown E, Nuño T, Giuliano A, et al.
Author(s): Snijders PJ, Verhoef VM, Arbyn M, Ogilvie G, Minozzi S, et al.
Author(s): Castle PE, Rodriguez AC, Porras C, Herrero R, Schiffman M, et al.
Author(s): De Alba I, Anton-Culver H, Hubbell FA, Ziogas A, Hess JR, et al.
Author(s): Igidbashian S, Boveri S, Spolti N, Radice D, Sandri MT, et al.
Author(s): Sellors JW, Lorincz AT, Mahony JB, Mielzynska I, Lytwyn A, et al.
Author(s): Enerly E, Olofsson C, Nygård M
Author(s): Szarewski A, Cadman L, Ashdown-Barr L, Waller J
Author(s): Petignat P, Vassilakos P
Author(s): Widdice LE, Moscicki AB
Author(s): American College of Obstetricians and Gynecologists