Author(s): Castle PE, Rodriguez AC, Porras C, Herrero R, Schiffman M, et al.
Objectives: We wanted to compare detection of a broad spectrum of human papillomavirus (HPV) types detected in cellular specimens from the vagina and cervix, which could provide information about the potential of each anatomical site for harboring infection. Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells.
Study design: We conducted follow-up study of 353 women who had participated in study of HPV and cervical neoplasia in Costa Rica. We collected paired cervical and vaginal specimens; vaginal specimens were collected from the fornix to minimize cervical contamination. Specimens were tested in a masked fashion for >40 HPV types using a MY09/MY11 PCR method and type-specific dot blot hybridization.
Results: The prevalence for any carcinogenic HPV type in vaginal and cervical specimens was similar (P = 0.3). However, the prevalence for any HPV type in vaginal specimens was greater than in cervical specimens (P = 0.0002), primarily due to a twofold increased vaginal prevalence of HPV types of the alpha3/alpha15 phylogenetic species (e.g., HPV61) (P <0.00005).
Conclusions: Carcinogenic HPV types appeared to have a similar affinity for vaginal and cervical epithelium, but noncarcinogenic HPV types of the alpha3/alpha15 phylogenetic species may have a tropism for vaginal epithelium.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17621246
Author(s): Safaeian M, Kiddugavu M, Gravitt PE, Ssekasanvu J, Murokora D, et al.
Author(s): Lack N, West B, Jeffries D, Ekpo G, Morison L, et al.
Author(s): Jones HE, Wiegerinck MA, Nieboer TE, Mol BW, Westhoff CL
Author(s): Deleré Y, Schuster M, Vartazarowa E, Hänsel T, Hagemann I, et al.
Author(s): Petignat P, Faltin DL, Bruchim I, Tramèr MR, Franco EL, et al.
Author(s): Mollers M, Scherpenisse M, van der Klis FR, King AJ, van Rossum TG, et al.
Author(s): Chranioti A, Aga E, Margari N, Kottaridi C, Pappas A, et al.
Author(s): Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, et al.
Author(s): Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, et al.
Author(s): Petignat P, Hankins C, Walmsley S, Money D, Provencher D, et al.
Author(s): Jones HE, Allan BR, van de Wijgert JH, Altini L, Taylor SM, et al.
Author(s): Kahn JA, Slap GB, Huang B, Rosenthal SL, Wanchick AM, et al.
Author(s): Karwalajtys T, Howard M, Sellors JW, Kaczorowski J
Author(s): Agorastos T, Dinas K, Lloveras B, Font R, Kornegay JR, et al.
Author(s): Baldwin S, Santos C, Mendez Brown E, Nuño T, Giuliano A, et al.
Author(s): Snijders PJ, Verhoef VM, Arbyn M, Ogilvie G, Minozzi S, et al.
Author(s): De Alba I, Anton-Culver H, Hubbell FA, Ziogas A, Hess JR, et al.
Author(s): Igidbashian S, Boveri S, Spolti N, Radice D, Sandri MT, et al.
Author(s): Sellors JW, Lorincz AT, Mahony JB, Mielzynska I, Lytwyn A, et al.
Author(s): Enerly E, Olofsson C, Nygård M
Author(s): Szarewski A, Cadman L, Ashdown-Barr L, Waller J
Author(s): Petignat P, Vassilakos P
Author(s): Widdice LE, Moscicki AB
Author(s): American College of Obstetricians and Gynecologists