Author(s): Parnell JA, Raman M, Rioux KP, Reimer RA
Non-alcoholic fatty liver disease (NAFLD) and the more severe non-alcoholic steatohepatitis (NASH) represent a spectrum of diseases involving hepatic fat accumulation and histological features essentially identical to alcoholic liver disease; however, they occur in the absence of excessive alcohol intake. They typically arise in conjunction with one or more features of the metabolic syndrome. Lifestyle mediated weight loss remains the primary mode of therapy for NAFLD and NASH, but this is often ineffective and adjunctive medical and surgical treatments are presently lacking. Prebiotic fibres are a group of non-digestible carbohydrates that modulate the human microbiota in a manner that is advantageous to host health. Rodent studies suggest that dietary supplementation with prebiotic fibres positively impacts NAFLD by modifying the gut microbiota, reducing body fat, and improving glucoregulation. Future research should focus on placebo-controlled, human, clinical trials using histological endpoints to address the effects of prebiotics on NAFLD and NASH. The aim of this review is to summarize current knowledge about prebiotics as an emerging therapeutic target for NAFLD.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22221818
Author(s): Arab JP, Candia R, Zapata R, Muñoz C, Arancibia JP, et al.
Author(s): Machado MV, Cortez-Pinto H1
Author(s): Aron-Wisnewsky J, Gaborit B, Dutour A, Clement K
Author(s): Lambert JE, Ramos-Roman MA2, Browning JD3, Parks EJ4
Author(s): Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al.
Author(s): Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al.
Author(s): Tateya S, Kim F, Tamori Y
Author(s): Gangarapu V, Yıldız K, Ince AT, Baysal B
Author(s): Miura K, Ohnishi H1
Author(s): Machado M, Marques-Vidal P, Cortez-Pinto H
Author(s): Anstee QM, Targher G, Day CP
Author(s): Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, et al.
Author(s): Goel A, Gupta M, Aggarwal R
Author(s): Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, et al.
Author(s): Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, et al.
Author(s): Musso G, Gambino R, Cassader M
Author(s): Tilg H, Kaser A
Author(s): Ley RE, Turnbaugh PJ, Klein S, Gordon JI
Author(s): Schwiertz A, Taras D, Schäfer K, Beijer S, Bos NA, et al.
Author(s): Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, et al.
Author(s): Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, et al.
Author(s): Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, et al.
Author(s): Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI
Author(s): Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, et al.
Author(s): Parekh PJ, Arusi E, Vinik AI2, Johnson DA3
Author(s): Shen J, Obin MS, Zhao L
Author(s): Lin HV, Frassetto A, Kowalik EJ Jr, Nawrocki AR, Lu MM, et al.
Author(s): Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, et al.
Author(s): Spor A, Koren O, Ley R
Author(s): Caricilli AM, Saad MJ
Author(s): Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al.
Author(s): Zhao L, Hu P, Zhou Y, Purohit J, Hwang D
Author(s): Tamrakar AK, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, et al.
Author(s): Winder WW, Hardie DG
Author(s): Tilg H, Moschen AR
Author(s): Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G
Author(s): Kim KA, Gu W, Lee IA, Joh EH, Kim DH
Author(s): Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, et al.
Author(s): Takaki A, Kawai D, Yamamoto K
Author(s): Ye D, Li FY, Lam KS, Li H, Jia W, et al.
Author(s): Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, et al.
Author(s): Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, et al.
Author(s): Himes RW, Smith CW
Author(s): Rivera CA, Gaskin L, Allman M, Pang J, Brady K, et al.
Author(s): Szabo G, Velayudham A, Romics L Jr, Mandrekar P
Author(s): Cario E, Gerken G, Podolsky DK
Author(s): Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, et al.
Author(s): Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al.
Author(s): Chen GY, Liu M, Wang F, Bertin J, Núñez G
Author(s): Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al.
Author(s): Wlodarska M, Thaiss CA2, Nowarski R3, Henao-Mejia J3, Zhang JP4, et al.
Author(s): Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J, et al.
Author(s): Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, et al.
Author(s): Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, et al.
Author(s): Bergheim I, Weber S, Vos M, Krämer S, Volynets V, et al.
Author(s): Gibson GR, Roberfroid MB
Author(s): Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB
Author(s): Slavin J1
Author(s): Macfarlane S, Macfarlane GT, Cummings JH
Author(s): Parnell JA, Reimer RA
Author(s): Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, et al.
Author(s): Levrat MA, Rémésy C, Demigné C
Author(s): Topping DL, Clifton PM
Author(s): Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, et al.
Author(s): Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, et al.
Author(s): Beylot M1
Author(s): Parnell JA, Reimer RA
Author(s): Sanders ME1
Author(s): Iacono A, Raso GM, Canani RB, Calignano A, Meli R
Author(s): Ma YY, Li L, Yu CH, Shen Z, Chen LH, et al.