Author(s): Shen J, Obin MS, Zhao L
The human gut is densely populated by commensal and symbiotic microbes (the "gut microbiota"), with the majority of the constituent microorganisms being bacteria. Accumulating evidence indicates that the gut microbiota plays a significant role in the development of obesity, obesity-associated inflammation and insulin resistance. In this review we discuss molecular and cell biological mechanisms by which the microbiota participate in host functions that impact the development and maintenance of the obese state, including host ingestive behavior, energy harvest, energy expenditure and fat storage. We additionally explore the diverse signaling pathways that regulate gut permeability and bacterial translocation to the host and how these are altered in the obese state to promote the systemic inflammation ("metabolic endotoxemia") that is a hallmark of obesity and its complications. Fundamental to our discussions is the concept of "crosstalk", i.e., the biochemical exchange between host and microbiota that maintains the metabolic health of the superorganism and whose dysregulation is a hallmark of the obese state. Differences in community composition, functional genes and metabolic activities of the gut microbiota appear to distinguish lean vs obese individuals, suggesting that gut 'dysbiosis' contributes to the development of obesity and/or its complications. The current challenge is to determine the relative importance of obesity-associated compositional and functional changes in the microbiota and to identify the relevant taxa and functional gene modules that promote leanness and metabolic health. As diet appears to play a predominant role in shaping the microbiota and promoting obesity-associated dysbiosis, parallel initiatives are required to elucidate dietary patterns and diet components (e.g., prebiotics, probiotics) that promote healthy gut microbiota. How the microbiota promotes human health and disease is a rich area of investigation that is likely to generate fundamental discoveries in energy metabolism, molecular endocrinology and immunobiology and may lead to new strategies for prevention of obesity and its complications.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/23159341
Author(s): Arab JP, Candia R, Zapata R, Muñoz C, Arancibia JP, et al.
Author(s): Machado MV, Cortez-Pinto H1
Author(s): Aron-Wisnewsky J, Gaborit B, Dutour A, Clement K
Author(s): Lambert JE, Ramos-Roman MA2, Browning JD3, Parks EJ4
Author(s): Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al.
Author(s): Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al.
Author(s): Tateya S, Kim F, Tamori Y
Author(s): Gangarapu V, Yıldız K, Ince AT, Baysal B
Author(s): Miura K, Ohnishi H1
Author(s): Machado M, Marques-Vidal P, Cortez-Pinto H
Author(s): Anstee QM, Targher G, Day CP
Author(s): Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, et al.
Author(s): Goel A, Gupta M, Aggarwal R
Author(s): Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, et al.
Author(s): Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, et al.
Author(s): Musso G, Gambino R, Cassader M
Author(s): Tilg H, Kaser A
Author(s): Ley RE, Turnbaugh PJ, Klein S, Gordon JI
Author(s): Schwiertz A, Taras D, Schäfer K, Beijer S, Bos NA, et al.
Author(s): Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, et al.
Author(s): Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, et al.
Author(s): Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, et al.
Author(s): Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI
Author(s): Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, et al.
Author(s): Parekh PJ, Arusi E, Vinik AI2, Johnson DA3
Author(s): Lin HV, Frassetto A, Kowalik EJ Jr, Nawrocki AR, Lu MM, et al.
Author(s): Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, et al.
Author(s): Spor A, Koren O, Ley R
Author(s): Caricilli AM, Saad MJ
Author(s): Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al.
Author(s): Zhao L, Hu P, Zhou Y, Purohit J, Hwang D
Author(s): Tamrakar AK, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, et al.
Author(s): Winder WW, Hardie DG
Author(s): Tilg H, Moschen AR
Author(s): Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G
Author(s): Kim KA, Gu W, Lee IA, Joh EH, Kim DH
Author(s): Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, et al.
Author(s): Takaki A, Kawai D, Yamamoto K
Author(s): Ye D, Li FY, Lam KS, Li H, Jia W, et al.
Author(s): Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, et al.
Author(s): Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, et al.
Author(s): Himes RW, Smith CW
Author(s): Rivera CA, Gaskin L, Allman M, Pang J, Brady K, et al.
Author(s): Szabo G, Velayudham A, Romics L Jr, Mandrekar P
Author(s): Cario E, Gerken G, Podolsky DK
Author(s): Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, et al.
Author(s): Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al.
Author(s): Chen GY, Liu M, Wang F, Bertin J, Núñez G
Author(s): Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al.
Author(s): Wlodarska M, Thaiss CA2, Nowarski R3, Henao-Mejia J3, Zhang JP4, et al.
Author(s): Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J, et al.
Author(s): Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, et al.
Author(s): Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, et al.
Author(s): Bergheim I, Weber S, Vos M, Krämer S, Volynets V, et al.
Author(s): Gibson GR, Roberfroid MB
Author(s): Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB
Author(s): Slavin J1
Author(s): Parnell JA, Raman M, Rioux KP, Reimer RA
Author(s): Macfarlane S, Macfarlane GT, Cummings JH
Author(s): Parnell JA, Reimer RA
Author(s): Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, et al.
Author(s): Levrat MA, Rémésy C, Demigné C
Author(s): Topping DL, Clifton PM
Author(s): Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, et al.
Author(s): Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, et al.
Author(s): Beylot M1
Author(s): Parnell JA, Reimer RA
Author(s): Sanders ME1
Author(s): Iacono A, Raso GM, Canani RB, Calignano A, Meli R
Author(s): Ma YY, Li L, Yu CH, Shen Z, Chen LH, et al.
