Author(s): Winder WW, Hardie DG
Adenosine 5'-monophosphate-activated protein kinase (AMPK) now appears to be a metabolic master switch, phosphorylating key target proteins that control flux through metabolic pathways of hepatic ketogenesis, cholesterol synthesis, lipogenesis, and triglyceride synthesis, adipocyte lipolysis, and skeletal muscle fatty acid oxidation. Recent evidence also implicates AMPK as being responsible for mediating the stimulation of glucose uptake induced by muscle contraction. In addition, the secretion of insulin by insulin secreting (INS-1) cells in culture is modulated by AMPK activation. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation and ketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake, and modulation of insulin secretion by pancreatic beta-cells. In skeletal muscle, AMPK is activated by contraction. Type 2 diabetes mellitus is likely to be a disease of numerous etiologies. However, defects or disuse (due to a sedentary lifestyle) of the AMPK signaling system would be predicted to result in many of the metabolic perturbations observed in Type 2 diabetes mellitus. Increased recruitment of the AMPK signaling system, either by exercise or pharmaceutical activators, may be effective in correcting insulin resistance in patients with forms of impaired glucose tolerance and Type 2 diabetes resulting from defects in the insulin signaling cascade.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10409121
Author(s): Arab JP, Candia R, Zapata R, Muñoz C, Arancibia JP, et al.
Author(s): Machado MV, Cortez-Pinto H1
Author(s): Aron-Wisnewsky J, Gaborit B, Dutour A, Clement K
Author(s): Lambert JE, Ramos-Roman MA2, Browning JD3, Parks EJ4
Author(s): Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al.
Author(s): Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al.
Author(s): Tateya S, Kim F, Tamori Y
Author(s): Gangarapu V, Yıldız K, Ince AT, Baysal B
Author(s): Miura K, Ohnishi H1
Author(s): Machado M, Marques-Vidal P, Cortez-Pinto H
Author(s): Anstee QM, Targher G, Day CP
Author(s): Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, et al.
Author(s): Goel A, Gupta M, Aggarwal R
Author(s): Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, et al.
Author(s): Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, et al.
Author(s): Musso G, Gambino R, Cassader M
Author(s): Tilg H, Kaser A
Author(s): Ley RE, Turnbaugh PJ, Klein S, Gordon JI
Author(s): Schwiertz A, Taras D, Schäfer K, Beijer S, Bos NA, et al.
Author(s): Duncan SH, Lobley GE, Holtrop G, Ince J, Johnstone AM, et al.
Author(s): Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, et al.
Author(s): Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, et al.
Author(s): Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI
Author(s): Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, et al.
Author(s): Parekh PJ, Arusi E, Vinik AI2, Johnson DA3
Author(s): Shen J, Obin MS, Zhao L
Author(s): Lin HV, Frassetto A, Kowalik EJ Jr, Nawrocki AR, Lu MM, et al.
Author(s): Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, et al.
Author(s): Spor A, Koren O, Ley R
Author(s): Caricilli AM, Saad MJ
Author(s): Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al.
Author(s): Zhao L, Hu P, Zhou Y, Purohit J, Hwang D
Author(s): Tamrakar AK, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, et al.
Author(s): Tilg H, Moschen AR
Author(s): Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G
Author(s): Kim KA, Gu W, Lee IA, Joh EH, Kim DH
Author(s): Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, et al.
Author(s): Takaki A, Kawai D, Yamamoto K
Author(s): Ye D, Li FY, Lam KS, Li H, Jia W, et al.
Author(s): Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, et al.
Author(s): Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, et al.
Author(s): Himes RW, Smith CW
Author(s): Rivera CA, Gaskin L, Allman M, Pang J, Brady K, et al.
Author(s): Szabo G, Velayudham A, Romics L Jr, Mandrekar P
Author(s): Cario E, Gerken G, Podolsky DK
Author(s): Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, et al.
Author(s): Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al.
Author(s): Chen GY, Liu M, Wang F, Bertin J, Núñez G
Author(s): Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, et al.
Author(s): Wlodarska M, Thaiss CA2, Nowarski R3, Henao-Mejia J3, Zhang JP4, et al.
Author(s): Anand PK, Malireddi RK, Lukens JR, Vogel P, Bertin J, et al.
Author(s): Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, et al.
Author(s): Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, et al.
Author(s): Bergheim I, Weber S, Vos M, Krämer S, Volynets V, et al.
Author(s): Gibson GR, Roberfroid MB
Author(s): Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB
Author(s): Slavin J1
Author(s): Parnell JA, Raman M, Rioux KP, Reimer RA
Author(s): Macfarlane S, Macfarlane GT, Cummings JH
Author(s): Parnell JA, Reimer RA
Author(s): Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, et al.
Author(s): Levrat MA, Rémésy C, Demigné C
Author(s): Topping DL, Clifton PM
Author(s): Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, et al.
Author(s): Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, et al.
Author(s): Beylot M1
Author(s): Parnell JA, Reimer RA
Author(s): Sanders ME1
Author(s): Iacono A, Raso GM, Canani RB, Calignano A, Meli R
Author(s): Ma YY, Li L, Yu CH, Shen Z, Chen LH, et al.