Author(s): Winchester DS, Hocker TL, Brewer JD
Superficial leiomyosarcoma (LMS) is a rare tumor with important clinical, pathologic, and treatment features. Previous LMS studies have included few patients, included minimal follow-up, and typically combined the superficial and subfascial (deep) forms.
ObjectiveWe sought to characterize clinical features, effectiveness of treatment approaches, and long-term outcomes for LMS stratified by depth of invasion.
MethodsIn all, 71 cases of primary superficial LMS, 48 dermal and 23 subcutaneous (mean follow-up of 8 years), were examined and clinical, histopathologic, and treatment factors reported.
ResultsTumor size and subcutaneous classification correlated with greater likelihood of metastasis and death at 5 years. When superficial LMS metastasizes, other skin sites are the most common distant location. Treatment with wide local excision with minimum 1-cm margins showed statistically lower rates of recurrences and metastasis compared with excision with narrow surgical margins. Fourteen cases of Mohs micrographic surgery had no recurrences or metastases. Five cases of dermal LMS metastasized, 2 of which resulted in death.
Author(s): Hung GY, Horng JL, Chen PC
Author(s): Mayerhofer K, Obermair A, Windbichler G
Author(s): Bharambe BM, Deshpande KA, Surase SG, Ajmera AP
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Author(s): Yanai H, Wani Y, Notohara K, Takada S, Yoshino T
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Author(s): Liao WC, Wang YC, Ma H
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Author(s): Svarvar C, Bohling T, Berlin O