Malignant transformation of leiomyoma of uterus to leiomyosarcoma with metastasis to ovary

Author(s): Bharambe BM, Deshpande KA, Surase SG, Ajmera AP


Uterine leiomyoma is the most common tumor found in women of reproductive age group. The clinical symptoms and severity usually depend upon the size, position, and number of fibroids present. The incidence of sarcomas in patients operated for leiomyomas is 0.23 % [1], with leiomyosarcoma being rarer estimated to be between 0.13 and 0.29 % [1, 2]. Uterine leiomyosarcoma comprises ~1 % of all uterine malignancies—average age of occurrence being 40–50 years. Metastasis from leiomyosarcoma of uterus occurs mainly to lung, liver, brain, kidney, and bones. Secondaries to ovary from uterine leiomyosarcomas are, however, very rare (3.5 %).

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