Author(s): Mayerhofer K, Obermair A, Windbichler G
Objective. The aim of this study was to evaluate the behavior of uterine leiomyosarcomas in relation to their clinical and pathologic features and to identify possible prognostic factors.
Methods. Seventy-one patients with histologically proven uterine leiomyosarcoma were included in the analysis. Leiomyosarcomas were defined as uterine smooth-muscle tumors with five or more mitoses per 10 high-power fields and cytologic atypia. Cox proportional hazards regression model was used to identify independent prognostic factors.
Results. The median follow-up time was 108 months; 5-year overall survival rate was 65%. Evaluating the correlation between several clinicopathologic parameters, tumors with vascular space involvement had a statistically significantly higher stage than tumors without vasular space involvement (P = 0.015). In a univariate Cox model early tumor stage (P < 0.0001), age <50 years (P < 0.0001), low mitotic count (P = 0.05), and the absence of vascular space involvement (P < 0.0005) were associated with good prognosis. In a multivariate analysis age (P = 0.002), tumor stage (P = 0.004), vascular space involvement (P = 0.003), and mitotic count in stage I tumors (P = 0.002) were found to be independent parameters for good prognosis in patients with uterine leiomyosarcoma.
Author(s): Hung GY, Horng JL, Chen PC
Author(s): Bharambe BM, Deshpande KA, Surase SG, Ajmera AP
Author(s): Rotmensch J, Bosnyak S, Montag A
Author(s): Yanai H, Wani Y, Notohara K, Takada S, Yoshino T
Author(s): Winchester DS, Hocker TL, Brewer JD
Author(s): Fields JP, Helwig EB
Author(s): Bernstein SC, Roenigk RK
Author(s): Choi JH, Ro JY
Author(s): Starr GF, Dockerty MB
Author(s): Humphreys TR, Finkelstein DH, Lee JB
Author(s): Rao UN, Finkelstein SD, Jones MW
Author(s): Starling J, Coldiron BM
Author(s): Liao WC, Wang YC, Ma H
Author(s): Zacher M, Heppt MV, Brinker TJ, Hayani KM, Flaig MJ, et al.
Author(s): Svarvar C, Bohling T, Berlin O