Synthesis, characterization and cytotoxicity study of magnetic (Fe 3 O 4) nanoparticles and their drug conjugate

Author(s): Banerji B, Pramanik SK, Mandal S, Maiti NC, Chaudhuri K


An easy synthesis of magnetic nanoparticles (Fe3O4) is described. Transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS) and X-ray diffraction (XRD) have been used to study the well dispersed and uniformly spherical nanoparticles. 5-Fluorouracil (5-FU) has been successfully loaded onto the nanoparticles and cytotoxicity studies were performed using a standard MTT assay. The results indicate that 5-fluorouracil-loaded iron nanoparticles are a more potent anticancer drugversus5-fluorouracil alone.

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