Author(s): Vialard F, Delanete A, Clement P, Simon-Bouy B, Aubriot FX, et al.
To examine sperm meiotic segregation in men with paracentric inversions.
DesignCases reports, literature review.
SettingDepartments of reproductive biology, cytogenetics, gynaecology, and obstetrics.
Patient(s)Two patients referred for infertility, heterozygous for a paracentric inversion.
Intervention(s)Fluorescence in situ hybridization (FISH) with specific probes and X/Y/18 centromeric probes on 1,000 spermatozoa for the 2 patients and 10 controls.
Main Outcome Measure(s)Sperm aneuploidy frequency.
Result(s)The FISH analysis using the specific probes for the paracentric inversion indicated low disequilibrium (0.4% and 0.5%). The FISH analysis using X/Y/18 centromeric probes indicated aneuploidy frequencies (0.3% and 1.1%), identical to those of control patients with the same sperm parameters.
Conclusion(s)Paracentric inversion seems to be associated with a very low risk of aneuploidy. A larger study is necessary to explore all chromosome inversions.
Author(s): Fryns JP, van den Berghe H
Author(s): Madan K
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Author(s): Bhatt SS, Manvelyan M, Moradkhani K, Hunstig F, Mrasek K, et al.
Author(s): Yapan C, Beyazyurek C, Ekmekci C, Kahraman S
Author(s): Amiel A, Sardos-Albertini F, Fejgin MD, Sharony R, Diukman R, et al.
Author(s): Anton E, Vidal F, Egozcue J, Blanco J
Author(s): Brown GM, Leversha M, Hulten M, Ferguson-Smith MA, Affara NA, et al.
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