Paracentric inversion inv(11)(q21q23) in The Netherlands

Author(s): Madan K, Pieters MH, Kuyt LP, van Asperen CJ, de Pater JM, et al.


We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant chromosomes arising from the inversion. It is doubtful whether prenatal diagnosis would be helpful to carriers of this inversion. The results of the genealogy study and geographical distribution are discussed; it is suggested that all the families have arisen from a single mutation.

Similar Articles

Sperm chromosome analysis in two cases of paracentric inversion

Author(s): Vialard F, Delanete A, Clement P, Simon-Bouy B, Aubriot FX, et al.

Inverted segment size and the presence of recombination hot spot clusters matter in sperm segregation analysis

Author(s): Bhatt SS, Manvelyan M, Moradkhani K, Hunstig F, Mrasek K, et al.

The Largest Paracentric Inversion, the Highest Rate of Recombinant Spermatozoa

Author(s): Yapan C, Beyazyurek C, Ekmekci C, Kahraman S

Genetic reproductive risk in inversion carriers

Author(s): Anton E, Vidal F, Egozcue J, Blanco J

Paracentric Inversions In Man

Author(s): Madan K, Seabright M, Lindenbaum RH, Bobrow M