Author(s): Raqib R, Roy SK, Rahman MJ, Azim T, Ameer SS, et al.
Background: Several studies showed benefits of long-term zinc supplementation on the incidence, severity, and duration of diarrhea and on the incidence of respiratory infections. Prolonged zinc supplementation also improves cell-mediated immunity in severely malnourished children.
Objective: We studied the effect of short-term zinc supplementation on intrinsic and specific immune and inflammatory responses in moderately malnourished children with acute shigellosis.
Design: A randomized, double-blind, placebo-controlled trial was conducted in Shigella-infected children aged 12-59 mo. Elemental zinc (20 mg) and a multivitamin containing vitamins A and D, thiamine, riboflavin, nicotinamide, and calcium at twice the recommended dietary allowance were given daily for 2 wk to the zinc group (n = 28), whereas the multivitamin alone was given to the control group (n = 28). Standard antibiotic therapy was given to all patients.
Results: Serum zinc concentrations increased in both groups during convalescence; however, zinc supplementation showed a significant effect. The lymphocyte proliferation response in the zinc group increased relative to that in the control group (P = 0.002), but no significant effects were seen on concentrations of cytokines (interleukin 2 and interferon gamma) released from mitogen-stimulated mononuclear cells or on concentrations of cytokines (interleukin 2, interferon gamma, and interleukin 1beta) in feces. Among the antigen [lipopolysaccharide and invasion plasmid-encoded antigen (Ipa)]-specific antibodies, plasma Ipa-specific immunoglobulin G responses at day 30 were significantly higher in the zinc group than in the control group. However, the 2 groups did not differ significantly in the other antigen-specific responses in plasma and stool.
Conclusion: A 14-d course of zinc supplementation during acute shigellosis increases the lymphocyte proliferation response and the Ipa-specific immunoglobulin G response.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/14985220
Author(s): Khan WA, Griffiths JK, Bennish ML
Author(s): Khan WA, Dhar U, Salam MA, Griffiths JK, Rand W, et al.
Author(s): RodrÃguez L, Cervantes E, Ortiz R
Author(s): Patwari AK
Author(s): Clemens JD, Stanton B, Stoll B, Shahid NS, Banu H, et al.
Author(s): Ahmed F, Clemens JD, Rao MR, Sack DA, Khan MR, et al.
Author(s): Dey SK, Chisti MJ, Das SK, Shaha CK, Ferdous F, et al.
Author(s): Ferdous F, Ahmed S, DAS SK, Farzana FD, Latham JR, et al.
Author(s): Rahman M, De Leener K, Goegebuer T, Wollants E, Van der Donck I, et al.
Author(s): Rahman M1, Sultana R, Ahmed G, Nahar S, Hassan ZM, et al.
Author(s): Qadri F, Khan AI, Faruque AS, Begum YA, Chowdhury F, et al.
Author(s): Qadri F, Das SK, Faruque AS, Fuchs GJ, Albert MJ, et al.
Author(s): Qadri F, Azim T, Chowdhury A, Hossain J, Sack RB, et al.
Author(s): Rahman M, Sack DA, Mahmood S, Hossain A
Author(s): Talukder KA, Islam Z, Islam MA, Dutta DK, Safa A, et al.
Author(s): de Onis M, Blössner M, Borghi E
Author(s): Haider R, Rasheed S, Sanghvi TG, Hassan N, Pachon H, et al.
Author(s): Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, et al.
Author(s): Meremikwu MM, Asindi AA, Antia-Obong OE
Author(s): Ashida H1, Nakano H, Sasakawa C
Author(s): Ashida H, Ogawa M, Kim M, Mimuro H, Sasakawa C
Author(s): Galán JE
Author(s): Rahman MM, McFadden G
Author(s): Brown KH, Parry L, Khatun M, Ahmed G
Author(s): Gurwith MJ, Williams TW
Author(s): Nathoo KJ, Porteous JE, Siziya S, Wellington M, Mason E
Author(s): Hossain S, Biswas R, Kabir I, Sarker S, Dibley M, et al.
Author(s): Schroeder GN, Hilbi H
Author(s): Kabir I, Butler T, Underwood LE, Rahman MM
Author(s): Henry FJ, Alam N, Aziz KM, Rahaman MM
Author(s): Rahman MJ, Sarker P, Roy SK, Ahmad SM, Chisti J, et al.