Author(s): Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, et al.
Osteonectin is a 32,000 dalton bone-specific protein that binds selectively to both hydroxyapatite and collagen. When osteonectin is bound to insolubilized type I collagen, the resultant complex binds synthetic apatite crystals and free calcium ions. The osteonectin-collagen complexes also nucleate mineral phase deposition from metastable balanced salt solutions, Antibodies to osteonectin cross-react with bone and, to a lesser extent, dentin, but not with other tissues. The protein is localized to mineralized bone trabeculae and occurs at higher levels in the matrix than in the cells of bone. These studies suggest that osteonectin is a tissue-specific protein, linking the bone mineral and collagen phases, perhaps initiating active mineralization in normal skeletal tissue.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/7034958
Author(s): Lane TF, Sage EH
Author(s): Sage H, Tupper J, Bramson R
Author(s): Weaver MS, Workman G, Sage EH
Author(s): Mayer U, Aumailley M, Mann K, Timpl R, Engel J
Author(s): Tremble PM, Lane TF, Sage EH, Werb Z
Author(s): Bradshaw AD
Author(s): Chlenski A, Cohn SL
Author(s): Bellahcène A, Castronovo V
Author(s): Barth PJ, Moll R, Ramaswamy A
Author(s): Mantoni TS, Schendel RR, Rödel F, Niedobitek G, Al-Assar O, et al.
Author(s): Lussier C, Sodek J, Beaulieu JF
Author(s): Yang E, Kang HJ, Koh KH, Rhee H, Kim NK, et al.
Author(s): Tai IT, Dai M, Owen DA, Chen LB
Author(s): Kalluri R, Zeisberg M
Author(s): Kacar A, Arikok AT, KokenekUnal TD, Onder E, Hucumenoglu S, et al.
Author(s): Paral KM, Taxy JB, Lingen MW
Author(s): Barth PJ, Ramaswamy A, Moll R
Author(s): Barth PJ, SchenckzuSchweinsberg T, Ramaswamy A, Moll R
Author(s): Chaudhary M, Gadbail AR, Vidhale G, MankarGadbail MP, Gondivkar SM, et al.
Author(s): Barth PJ, Ebrahimsade S, Hellinger A, Moll R, Ramaswamy A
Author(s): Nakayama H, Enzan H, Miyazaki E
Author(s): Darby I, Skalli O, Gabbiani G