Author(s): Kalluri R, Zeisberg M
Tumours are known as wounds that do not heal - this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/16572188
Author(s): Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, et al.
Author(s): Lane TF, Sage EH
Author(s): Sage H, Tupper J, Bramson R
Author(s): Weaver MS, Workman G, Sage EH
Author(s): Mayer U, Aumailley M, Mann K, Timpl R, Engel J
Author(s): Tremble PM, Lane TF, Sage EH, Werb Z
Author(s): Bradshaw AD
Author(s): Chlenski A, Cohn SL
Author(s): BellahcÃ¨ne A, Castronovo V
Author(s): Barth PJ, Moll R, Ramaswamy A
Author(s): Mantoni TS, Schendel RR, RÃ¶del F, Niedobitek G, Al-Assar O, et al.
Author(s): Lussier C, Sodek J, Beaulieu JF
Author(s): Yang E, Kang HJ, Koh KH, Rhee H, Kim NK, et al.
Author(s): Tai IT, Dai M, Owen DA, Chen LB
Author(s): Kacar A, Arikok AT, KokenekUnal TD, Onder E, Hucumenoglu S, et al.
Author(s): Paral KM, Taxy JB, Lingen MW
Author(s): Barth PJ, Ramaswamy A, Moll R
Author(s): Barth PJ, SchenckzuSchweinsberg T, Ramaswamy A, Moll R
Author(s): Chaudhary M, Gadbail AR, Vidhale G, MankarGadbail MP, Gondivkar SM, et al.
Author(s): Barth PJ, Ebrahimsade S, Hellinger A, Moll R, Ramaswamy A
Author(s): Nakayama H, Enzan H, Miyazaki E
Author(s): Darby I, Skalli O, Gabbiani G