Author(s): Paral KM, Taxy JB, Lingen MW
Objective: This study evaluated the use of stromal biomarkers CD34 and α smooth muscle actin (α-SMA) to distinguish verrucous carcinoma (VC) from verrucous hyperplasia (VH).
Study design: Thirteen VH, 15 VC, 20 squamous cell carcinoma (SCC), and 16 of uninvolved adjacent stroma specimens were analyzed for α-SMA and CD34 expression by immunohistochemistry.
Results: Stromal α-SMA positivity was observed in 100% (20 of 20) of the SCC and in 93% (14 of 15) of the VC, whereas none of the VH (0 of 13) or adjacent uninvolved stroma (0 of 16) demonstrated α-SMA reactivity. Stromal CD34 positivity was observed in 100% (13 of 13) of VH and adjacent stroma (16 of 16), while 20% (3 of 15) of VC and 11% (2 of 18) of SCC stroma expressed CD34. The SCC and VC groups differed significantly from the VH and uninvolved stroma groups for both α-SMA and CD34 expression (P < .0001).
Conclusions: Stromal CD34 and α-SMA protein expression patterns may aid in distinguishing between VC and VH in challenging cases.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/24560559
Author(s): Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, et al.
Author(s): Lane TF, Sage EH
Author(s): Sage H, Tupper J, Bramson R
Author(s): Weaver MS, Workman G, Sage EH
Author(s): Mayer U, Aumailley M, Mann K, Timpl R, Engel J
Author(s): Tremble PM, Lane TF, Sage EH, Werb Z
Author(s): Bradshaw AD
Author(s): Chlenski A, Cohn SL
Author(s): Bellahcène A, Castronovo V
Author(s): Barth PJ, Moll R, Ramaswamy A
Author(s): Mantoni TS, Schendel RR, Rödel F, Niedobitek G, Al-Assar O, et al.
Author(s): Lussier C, Sodek J, Beaulieu JF
Author(s): Yang E, Kang HJ, Koh KH, Rhee H, Kim NK, et al.
Author(s): Tai IT, Dai M, Owen DA, Chen LB
Author(s): Kalluri R, Zeisberg M
Author(s): Kacar A, Arikok AT, KokenekUnal TD, Onder E, Hucumenoglu S, et al.
Author(s): Barth PJ, Ramaswamy A, Moll R
Author(s): Barth PJ, SchenckzuSchweinsberg T, Ramaswamy A, Moll R
Author(s): Chaudhary M, Gadbail AR, Vidhale G, MankarGadbail MP, Gondivkar SM, et al.
Author(s): Barth PJ, Ebrahimsade S, Hellinger A, Moll R, Ramaswamy A
Author(s): Nakayama H, Enzan H, Miyazaki E
Author(s): Darby I, Skalli O, Gabbiani G