Author(s): Benjamin EJ, Levy D, Vaziri SM, D\'Agostino RB, Belanger AJ
Objective. —To determine the independent risk factors for atrial fibrillation.
Design. —Cohort study.
Setting. —The Framingham Heart Study.
Subjects. —A total of 2090 men and 2641 women members of the original cohort, free of a history of atrial fibrillation, between the ages of 55 and 94 years.
Main Outcome Measures. —Sex-specific multiple logistic regression models to identify independent risk factors for atrial fibrillation, including age, smoking, diabetes, electrocardiographic left ventricular hypertrophy, hypertension, myocardial infarction, congestive heart failure, and valve disease.
Results. —During up to 38 years of follow-up, 264 men and 298 women developed atrial fibrillation. After adjusting for age and other risk factors for atrial fibrillation, men had a 1.5 times greater risk of developing atrial fibrillation than women. In the full multivariable model, the odds ratio (OR) of atrial fibrillation for each decade of advancing age was 2.1 for men and 2.2 for women (P<.0001). In addition, after multivariable adjustment, diabetes (OR, 1.4 for men and 1.6 for women), hypertension (OR, 1.5 for men and 1.4 for women), congestive heart failure (OR, 4.5 for men and 5.9 for women), and valve disease (OR, 1.8 for men and 3.4 for women) were significantly associated with risk for atrial fibrillation in both sexes. Myocardial infarction (OR, 1.4) was significantly associated with the development of atrial fibrillation in men. Women were significantly more likely than men to have valvular heart disease as a risk factor for atrial fibrillation. The multivariable models were largely unchanged after eliminating subjects with valvular heart disease.
Referred From: https://jama.jamanetwork.com/article.aspx?articleid=367563
Author(s): Ott A, Breteler MM, de Bruyne MC, van Harskamp F, Grobbee DE
Author(s): Wolf PA, Abbott RD, Kannel WB
Author(s): Furberg CD, Psaty BM, Manolio TA, Gardin JM, Smith VE
Author(s): Wagner KH, Brath H
Author(s): Rizzo JA, Mallow P, Waters H, Cirrincione A
Author(s): Jorgensen HS, Nakayama H, Reith J, Raaschou HO, Olsen TS
Author(s): Fuster V, Ryden LE, Asinger RW, Cannom DS, Crijns HJ
Author(s): Tsang TS, Petty GW, Barnes ME, O\'Fallon WM, Bailey KR
Author(s): Steger C, Pratter A, Martinek-Bregel M, Avanzini M, Valentin A
Author(s): Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB
Author(s): Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J,
Author(s): Ball J, Carrington MJ, McMurray JJ, Stewart S
Author(s): Glader EL, Stegmayr B, Norrving B, Terént A, Hulter-Asberg K
Author(s): Sinner MF, Ellinor PT, Meitinger T, Benjamin EJ, Kääb S
Author(s): Dewland TA, Olgin JE, Vittinghoff E, Marcus GM
Author(s): Hernandez MB, Asher CR, Hernandez AV, Novaro GM
Author(s): Gan R, Sacco RL, Kargman DE, Roberts JK, Boden-Albala B
Author(s): Ruigomez A, Johansson S, Wallander MA, Rodriguez LA
Author(s): Stewart S, Hart CL, Hole DJ, McMurray JJ
Author(s): Psaty BM, Manolio TA, Kuller LH, Kronmal RA, Cushman M
Author(s): Barnes ME, Miyasaka Y, Seward JB, Gersh BJ, Rosale s AG
Author(s): Dulli DA, Stanko H, Levine RL
Author(s): Lamassa M, Di Carlo A, Pracucci G, Basile AM, Trefoloni G
Author(s): Lin HJ, Wolf PA, Kelly-Hayes M, Beiser AS, Kase CS
Author(s): Friberg J, Buch P, Scharling H, Gadsbphioll N, Jensen GB
Author(s): Kim MH, Lin J, Hussein M, Battleman D
Author(s): Miyasaka Y, Barnes ME, Gersh BJ, Cha SS, Bailey KR,
Author(s): Wattigney WA, Mensah GA, Croft JB
Author(s): Keogh AM, Baron DW, Hickie JB
Author(s): Markides V, Schilling RJ
