Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.

Author(s): Wolf PA, Abbott RD, Kannel WB

Abstract

The impact of nonrheumatic atrial fibrillation, hypertension, coronary heart disease, and cardiac failure on stroke incidence was examined in 5,070 participants in the Framingham Study after 34 years of follow-up. Compared with subjects free of these conditions, the age-adjusted incidence of stroke was more than doubled in the presence of coronary heart disease (/?< 0.001) and more than trebled in the presence of hypertension (p50% of stroke events were prevented by warfarin anticoagulation. (Stroke 1991^2:983-988)

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