Author(s): Pace C, Markowitz M
Purpose of review: Clinically relevant monoclonal antibodies (mAb) to host cellular receptors have been generated to both the CD4 receptor and the CCR5 coreceptor, cell surface proteins critical for HIV-1 entry. Ibalizumab is a novel humanized mAb that binds to a conformational epitope on CD4 and blocks entry of HIV-1. It has broad and potent antiviral activity in vitro and in vivo. PRO 140 is a humanized mAb that binds to the CCR5 coreceptor and inhibits CCR5-tropic HIV-1 by interfering with viral entry. Antiviral activity has been demonstrated both in vitro against R5 viruses and in vivo in HIV-1-infected individuals harboring CCR5-tropic virus.
Recent findings: Both antibodies have been administered intravenously in early-phase clinical trials, and current emphasis is on the development of formulations that can be administered subcutaneously. Most recently, bispecific antibodies combining either ibalizumab or PRO 140 with anti-Env broadly neutralizing antibodies have been constructed with vastly improved in-vitro neutralizing profiles, and may offer substantial advantages in the clinic.
Referred From: https://pubmed.ncbi.nlm.nih.gov/25700204/
Author(s): Barry SM, Mena Lora AJ, Novak RM
Author(s): Van Gils MJ, Sanders RW
Author(s): Haynes BF, Moody MA, Liao HX, Verkoczy L, Tomaras GD
Author(s): Wyatt R, Kwong PD, Desjardins E, Sweet RW, Robinson J, et al.
Author(s): Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, et al.
Author(s): Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, et al.
Author(s): McBurney SP , Ross TM.
Author(s): Zhang Z, Li S, Gu Y, Xia N
Author(s): Berkhout B, Sanders RW
Author(s): Balazs AB, West AP
Author(s): Nguyen M, Huan-Tu G, Gonzalez-Edick M, Rivera VM, Clackson T, et al.
Author(s): Fang J, Yi S, Simmons A, Tu GH, Nguyen M, et al.
Author(s): Liu R, Paxton WA, Choe S, Ceradini D, Martin SR et al.
Author(s): Hütter G, Nowak D, Mossner M, Ganepola S, Müßig A, et al.
Author(s): Dau B, Holodniy M.
Author(s): Barry SM, Lora AJM, Novak RM.
Author(s): Schiller J, Chackerian B
Author(s): US National library of Medicine
Author(s): US National library of Medicine
Author(s): US National library of Medicine
Author(s): Scharf L, Wang H, Gao H, Chen S, McDowall AW, et al.
Author(s): US National library of Medicine
Author(s): US National library of Medicine
Author(s): US National library of Medicine
Author(s): Zhang Z, Li S, Gu Y, Xia N
Author(s): Yang L, Wang P