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Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
Referred From: http://www.nejm.org/doi/full/10.1056/NEJMoa0802905
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Author(s): US National library of Medicine
Author(s): US National library of Medicine
Author(s): US National library of Medicine
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Author(s): US National library of Medicine
Author(s): US National library of Medicine
Author(s): US National library of Medicine
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