Citrus limon Burm f

Hypolipidemic screening of MFEt of W. coagulans, ESEt of C. anthelminticum and C. limon was conducted by using single dose (200 mg/kg) of each for 14 days in normal overnight fasted rabbits, where W. coagulans and C. anthelminticum gave significant activity. These later subjected to evaluate the hypolipidemic and antioxidant effects in triton X-100 induced hyperlipidemic rabbits. Animals were divided into control and triton-induced hyperlipidemic (TIH) groups. The TIH group was further divided into TIH control, negative control, positive control (simvastatin) and four test groups, treated with MFEt of W. coagulans and ESEt of C. anthelminticum @ 200 and 600 mg/kg respectively. After 18 hours, rabbits were sacrificed to estimate lipid profile, ALT, CK, CAT, SOD, LPO, HMG-CoA reductase, lipase, atherogenic index (AI) and percent protection. The results demonstrated that both doses of W. coagulans and C. anthelminticum significantly improved lipid profile, HMG-CoA reductase & lipase activities and antioxidant status of test rabbits. AI was significantly decreased and percent protection was increased by both plant extracts in test groups. It was concluded that W. coagulans and C. anthelminticum showed good protection against hyperlipidemia and hyperlipidemia-induced oxidative stress by decreasing levels of serum lipids and improving the efficiency of antioxidant enzymes, thereby decreasing the risk of atherogenesis.