Author(s): Chang A
Management of patients with lung cancer continues to pose a considerable challenge to today's oncologist. While treatment may be curative in the early stages of the disease, the majority of patients are not diagnosed until the tumor has progressed beyond the primary site. Most patients face an intensive and invasive treatment regimen comprising surgery, radiotherapy, or chemotherapy, or combinations thereof depending on disease stage/performance status. Most will require chemotherapy even if their initial surgery is potentially curative; for those with advanced disease, chemotherapy may be their only treatment option. Moreover, the majority of patients will require multiple lines of therapy as their cancer cells acquire resistance to the chemotherapeutic agents to which they are exposed. Resistance to current chemotherapeutics available for the management of non-small cell lung cancer (NSCLC) represents one of the most significant barriers to improving long-term outcomes for this vulnerable patient group. Future management may lie in individualizing therapy through careful selection of appropriate agents based on the likelihood of response and the development of resistance. A number of biomarkers are emerging that predict response to current therapeutics; work is ongoing to develop appropriate algorithms based on such markers to guide treatment selection. In addition, novel chemotherapeutics are in development including new platinum analogs such as picoplatin (a cisplatin analog), ABT-751 (a sulfonamide) and tubulin binding agents (TBAs) such as the epothilones, providing hope for the future.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20951465
Author(s): Neal JW, Gubens MA, Wakelee HA
Author(s): Kartalou M, Essigmann JM
Author(s): Rabik CA, Dolan ME
Author(s): Siddik ZH
Author(s): Rosenberg ME, Silkensen J
Author(s): Niu ZH, Wang Y, Chun B, Li CX, Wu L
Author(s): Zoubeidi A, Chi K, Gleave M
Author(s): Yang GF, Li XM, Xie D
Author(s): He LR, Liu MZ, Li BK, Rao HL, Liao YJ, et al.
Author(s): Xie MJ, Motoo Y, Su SB, Mouri H, Ohtsubo K, et al.
Author(s): Park DC, Yeo SG, Wilson MR, Yerbury JJ, Kwong J, et al.
Author(s): Wang Y, Wang X, Zhao H, Liang B, Du Q
Author(s): Chou TY, Chen WC, Lee AC, Hung SM, Shih NY, et al.
Author(s): Yan Y, Luo K, Zhang H, Chai W
Author(s): Cheng CY, Cherng SH, Wu WJ, Yang TY, Huang XY, et al.
Author(s): Laskin JJ, Nicholas G, Lee C, Gitlitz B, Vincent M, et al.
Author(s): Cao C, Shinohara ET, Li H, Niermann KJ, Kim KW, et al.
Author(s): Bortul R, Tazzari PL, Billi AM, Tabellini G, Mantovani I, et al.
Author(s): Liu D, Zhang Y, Dang C, Ma Q, Lee W, et al.
Author(s): Guinea Viniegra J, HernÃ¡ndez Losa J, SÃ¡nchez-ArÃ©valo VJ, ParadaCobo C, FernÃ¡ndezSoria VM, et al.
Author(s): McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, et al.
Author(s): McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, et al.
Author(s): Sridhar SS, Hedley D, Siu LL
Author(s): Tang Y, Liu F, Zheng C, Sun S, Jiang Y
Author(s): Si H, Peng C, Li J, Wang X, Zhai L, et al.
Author(s): Zhou L, Luan H, Liu Q, Jiang T, Liang H, et al.
Author(s): Li H, Schmid-Bindert G, Wang D, Zhao Y, Yang X, et al.
Author(s): Lee HY, Oh SH, Suh YA, Baek JH, Papadimitrakopoulou V, et al.
Author(s): Wang M, Liu ZM, Li XC, Yao YT, Yin ZX
Author(s): Li J, Jia L, Zhao P, Jiang Y, Zhong S, et al.
Author(s): Xiu P, Dong X, Dong X, Xu Z, Zhu H, et al.
Author(s): Ma X, Bai Y
Author(s): Scaltriti M, Bettuzzi S, Sharrard RM, Caporali A, Caccamo AE, et al.
Author(s): Manic S, Gatti L, Carenini N, Fumagalli G, Zunino F, et al.
Author(s): Springate CM, Jackson JK, Gleave ME, Burt HM
Author(s): Miyake H, Hara S, Zellweger T, Kamidono S, Gleave ME, et al.
Author(s): Hoeller C, Pratscher B, Thallinger C, Winter D, Fink D, et al.
Author(s): Redondo M, TÃ©llez T, Roldan MJ, Serrano A, GarcÃa-Aranda M, et al.
Author(s): Lourda M, Trougakos IP, Gonos ES
Author(s): Karaca B, Atmaca H, Bozkurt E, Kisim A, Uzunoglu S, et al.
Author(s): Pajak B, Orzechowski A
Author(s): Peyssonnaux C, EychÃ¨ne A
Author(s): Zhuang S, Schnellmann RG
Author(s): Ko JC, Tsai MS, Chiu YF, Weng SH, Kuo YH, et al.
Author(s): Gozdz A, Habas A, Jaworski J, Zielinska M, Albrecht J, et al.
Author(s): Huang WC, Hung MC
Author(s): Seo JH, Jeong ES, Lee KS, Heo SH, Jeong DG, et al.