Recommended Conferences


Amsterdam, Netherlands


Amsterdam, Netherlands


Amsterdam, Netherlands
Related Subjects

Antiproliferative activity of Vietnamese medicinal plants

Author(s): Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, et al.


Methanol, methanol-water (1:1) and water extracts were prepared from seventy-seven Vietnamese medicinal plants and tested for their antiproliferative activities against human HT-1080 fibrosarcoma cells. Among them, fifteen extracts including seven methanol extracts of Caesalpinia sappan, Catharanthus roseus, Coscinium fenestratum, Eurycoma longifolia, Hydnophytum formicarum and Streptocaulon juventas (collected at two areas), six methanol-water (1:1) extracts of Cae. sappan, Cat. roseus, Co. fenestratum, H. formicarum and S. juventas (at two areas), and two water extracts of Cae. sappan and S. juventas exhibited antiproliferative activities in a concentration-dependent manner. Their antiproliferative activities against human cervix HeLa adenocarcinoma, human lung A549 adenocarcinoma, murine colon 26-L5 carcinoma, murine Lewis lung carcinoma (LLC) and murine B16-BL6 melanoma cells were then examined. Co. fenestratum showed selective activity against lung carcinoma and/or lung metastatic cell lines, A549, LLC and B16-BL6, while H. formicarum and S. juventas showed selective activity against human tumor cell lines, HeLa and A549. Characteristic morphological change and DNA fragmentation indicated the antiproliferative activity to be due to the induction of apoptosis.

Similar Articles

Plants as a source of anti-cancer agents

Author(s): GM Cragg, DJ Newman

Anticancer effects of ethanolicneem leaf extract on prostate cancer cell line (PC-3)

Author(s): Kumar S, Suresh PK, Vijayababu MR, Arunkumar A, Arunakaran J


Author(s): R Baral, Chattopadhyay U ( 2004) Neem (Azadirachtaindica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma

Extract of Azadirachtaindica (Neem) leaf induces apoptosis in 4T1 breast cancer BALB/c mice

Author(s): Othman F, Motalleb G,Peng SLT,Rahmat A, Fakurazi S, et al.

Neem oil limonoids induces p53-independent apoptosis and autophagy

Author(s): Srivastava P, Yadav N, Lella R,Schneider A, Jones A, et al.

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

Author(s): Elumalai P, Gunadharini DN,Senthilkumar K, Banudevi S,Arunkumar R, et al.

Cancer ChemotherPharmacol Jul47:29-34

Author(s): Dale PS, Tamhankar CP, George D, Daftary GV ( 2001) Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects

Plant products protective against cancer

Author(s): Aruna K,Sivaramakrishnan VM

Anticarcinogenic effect of some Indian plant products

Author(s): Aruna K, Sivaramakrishnan VM

Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts

Author(s): Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, et al.

Isolation of indole alkaloids from Catharanthusroseus by centrifugal partition chromatography in the pH-zone refining mode

Author(s): Renault JH, Nuzillard JM, Le Crouérour G, Thépenier P, Zèches-Hanrot M, et al.