Author(s): de la Monte SM, Longato L, Tong M, DeNucci S, Wands JR
Alcohol abuse causes progressive toxicity and degeneration in liver and brain due to insulin resistance, which exacerbates oxidative stress and pro-inflammatory cytokine activation. Alcohol-induced steatohepatitis promotes synthesis and accumulation of ceramides and other toxic lipids that cause insulin resistance. Ceramides can readily cross the blood-brain barrier, and ceramide exposure causes neurodegeneration with insulin resistance and oxidative stress, similar to the effects of alcohol. Therefore, in addition to its direct neurotoxic effects, alcohol misuse establishes a liver-brain axis of neurodegeneration mediated by toxic lipid trafficking across the blood-brain barrier, leading to progressive white matter degeneration and cognitive impairment.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/19742171
Author(s): Miller AM, Horiguchi N, Jeong WI, Radaeva S, Gao B
Author(s): Paula H, Asrani SK, Boetticher NC, Pedersen R, Shah VH, et al.
Author(s): Purohit V, Gao B, Song BJ
Author(s): de la Monte SM, Yeon JE, Tong M, Longato L, Chaudhry R, et al.
Author(s): Denucci SM, Tong M, Longato L, Lawton M, Setshedi M, et al.
Author(s): He J, de la Monte S, Wands JR
Author(s): Onishi Y, Honda M, Ogihara T, Sakoda H, Anai M, et al.
Author(s): Pang M, de la Monte SM, Longato L, Tong M, He J, et al.
Author(s): Ronis MJ, Wands JR, Badger TM, de la Monte SM, Lang CH, et al.
Author(s): Sasaki Y, Wands JR
Author(s): Setshedi M, Longato L, Petersen DR, Ronis M, Chen WC, et al.
Author(s): Gao B, Bataller R
Author(s): Lieber CS
Author(s): Seth D, Haber PS, Syn WK, Diehl AM, Day CP
Author(s): Setshedi M, Wands JR, Monte SM
Author(s): Mohr L, Tanaka S, Wands JR
Author(s): Friedman SL, Nieto N
Author(s): Gyamfi MA, Wan YJ
Author(s): Yessoufou A, Wahli W
Author(s): Viana Abranches M, Esteves de Oliveira FC, Bressan J
Author(s): Heald M, Cawthorne MA
Author(s): Shah P, Mudaliar S
Author(s): Phielix E, Szendroedi J, Roden M
Author(s): Tailleux A, Wouters K, Staels B
Author(s): Promrat K, Lutchman G, Uwaifo GI, Freedman RJ, Soza A, et al.
Author(s): Enomoto N, Takei Y, Hirose M, Konno A, Shibuya T, et al.
Author(s): de la Monte SM, Pang M, Chaudhry R, Duan K, Longato L, et al.
Author(s): Tomita K, Azuma T, Kitamura N, Nishida J, Tamiya G, et al.
Author(s): Pandol SJ, Gorelick FS, Gerloff A, Lugea A
Author(s): Sozio MS, Liangpunsakul S, Crabb D
Author(s): Ronis MJ, Butura A, Korourian S, Shankar K, Simpson P, et al.
Author(s): Baumgardner JN, Shankar K, Hennings L, Badger TM, Ronis MJ
Author(s): Miller AM, Wang H, Bertola A, Park O, Horiguchi N, et al.
Author(s): Carmiel-Haggai M, Cederbaum AI, Nieto N
Author(s): Bailey SM, Mantena SK, Millender-Swain T, Cakir Y, Jhala NC, et al.
Author(s): Devi SL, Anuradha CV
Author(s): Tang Y, Forsyth CB, Banan A, Fields JZ, Keshavarzian A
Author(s): Uchida T, Kao H, Quispe-Sjogren M, Peters RL
Author(s): Junge J, Horn T, Christoffersen P
Author(s): Wakabayashi T, Horiuchi M, Sakaguchi M, Onda H, Iijima M
Author(s): Rømert P, Matthiessen ME
Author(s): Rømert P, Matthiessen ME
Author(s): Ronis MJ, Butura A, Sampey BP, Shankar K, Prior RL, et al.