Author(s): Shi P, Liu W, Zhou ZT, He QB, Jiang WW
Background: Oral lichen planus (OLP) is a potentially malignant disorder associated with an increased risk for oral cancer. The purpose of this study was to determine protein expression of podoplanin and ATP-binding cassette, G2 subfamily (ABCG2) in patients with OLP and evaluate their use as biomarkers for OLP malignant transformation risk.
Methods: Podoplanin and ABCG2 expressions were determined in samples from 110 patients with untransformed OLP and 9 patients with malignant transformed OLP (mean follow-up of 5.1 years). We compared podoplanin expression, ABCG2 expression, and clinicopathologic parameters between the two groups.
Results: Podoplanin expression was observed in 48 of 110 (43.6%) cases of untransformed OLP and in 8 of 9 (88.9%) cases of transformed OLP. ABCG2 expression was found in 23 of 110 (20.9%) cases of untransformed OLP and in 6 of 9 (66.7%) cases of transformed OLP. Multivariate regression analysis revealed that podoplanin or ABCG2 expression was associated with 17.13-fold [95% confidence interval (95% CI), 1.71-171.22; P = 0.016] or 6.04-fold (95% CI, 1.20-30.36; P = 0.029) increased risk of malignant transformation, respectively. The risk of OLP malignant transformation was considerably higher with coexpression of podoplanin and ABCG2 than without coexpression of podoplanin and ABCG2 (odds ratio, 25.24; 95% CI, 4.48-142.27; P < 0.001).
Conclusions: The expressions of podoplanin and ABCG2 in OLP were significantly associated with malignant transformation risk.
Impact: Our data suggested that podoplanin and ABCG2 may be used as biomarkers for risk assessment of oral malignant transformation in patients with OLP.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20200437
Author(s): Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, et al.
Author(s): Rodrigo JP, GarcÃa-Carracedo D, González MV, Mancebo G, Fresno MF, et al.
Author(s): Raica M, Cimpean AM, Ribatti D
Author(s): Lingen MW, Pinto A, Mendes RA, Franchini R, Czerninski R, et al.
Author(s): Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, et al.
Author(s): Matsui K, Breiteneder-Geleff S, Kerjaschki D
Author(s): Margaritescu C, Raica M, Pirici D, Simionescu C, Mogoanta L, et al.
Author(s): Miyazaki Y, Okamoto E, González-Alva P, Hayashi J, Ishige T, et al.
Author(s): Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, et al.
Author(s): Sawa Y, Iwasawa K, Ishikawa H
Author(s): Imaizumi Y, Amano I, Tsuruga E, Kojima H, Sawa Y
Author(s): González-Alva P, Inoue H, Miyazaki Y, Tsuchiya H, Noguchi Y, et al.
Author(s): Damante JH, Fleury RN
Author(s): Kawaguchi H, El-Naggar AK, Papadimitrakopoulou V, Ren H, Fan YH, et al.
Author(s): De Vicente JC, Rodrigo JP, Rodriguez-Santamarta T, Lequerica-Fernández P, Allonca E, et al.
Author(s): Margaritescu C, Raica M, Pirici D, Simionescu C, Mogoanta L, et al.
Author(s): Miyahara M, Tanuma J, Sugihara K, Semba I
Author(s): Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, et al.
Author(s): Wicki A, Christofori G
Author(s): Kunita A, Kashima TG, Morishita Y, Fukayama M, Kato Y, et al.
Author(s): MartÃn-Villar E, MegÃas D, Castel S, Yurrita MM, Vilaró S, et al.
Author(s): Atsumi N, Ishii G, Kojima M, Sanada M, Fujii S, et al.
Author(s): Wicki A, Christofori G
Author(s): Hata M, Amano I, Tsuruga E, Kojima H, Sawa Y
Author(s): Savera AT, Zarbo RJ
Author(s): Kanner WA, Galgano MT, Atkins KA
