Author(s): Vasenwala SM Beg S, Ansari HA, Haider N, Sharma R
It is rare to find osteoclastic giant cells (OGCs) as a stromal reaction in uterine adenocarcinoma of endometrium. Here, we report a case of a 60-year-old female diagnosed with adenocarcinoma of endometrium. Total hysterectomy with bilateral salpingo-oopherectomy and removal of pelvic lymphnodes was performed. Histologically, the tumour showed adenocarcinoma of the endometrium with mucin secretion. The stroma showed some plump reactive pleomorphic cells, resembling stromal cells, infiltrated uniformly with OGCs and mononuclear cells (MNCs). The epithelial cells of adenocarcinoma stained positive for cytokeratin (CK 7) (CAM 5.2). The osteoclastic giant cells and mononuclear cells stained positive with CD68 and negative with cytokeratin and vimentin. We conclude that the osteoclastic giant cells originated from reactive histiocytes/monocytes as a stromal reaction to malignancy.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21947360
Author(s): Jones MA Young RH, Scully RE
Author(s): Mulligan AM Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, et al.
Author(s): Akbulut M Tosun H, Soysal ME, Oztekin O
Author(s): Manglik N Sawicki J, Saad A, Fadare O, Soslow R, et al.
Author(s): Patai K Illyes G, Varbiro S, Gidai J, Kosa L, et al.
Author(s): Wang JC Su CC, Xu JB, Chen LZ, Hu XH, et al.
Author(s): Tong SY Lee JM, Choi YJ, Lee JK, Kim JW, et al.
Author(s): Lopez-Garcia MA Palacios J
Author(s): de Jong RA Nijman HW, Wijbrandi TF, Reyners AK, Boezen HM, et al.
Author(s): Voutsadakis IA
Author(s): Saegusa M Hashimura M, Kuwata T, Okayasu I
Author(s): Castilla MÃ Moreno-Bueno G, Romero-PÃ©rez L, Van De Vijver K, Biscuola M, et al.
Author(s): Mirantes C Espinosa I, Ferrer I, Dolcet X, Prat J, et al.
Author(s): Marusyk A Polyak K