Author(s): Ishii H, Azuma K, Kawahara A, Yamada K, Imamura Y, et al.
Background Programmed cell death 1 receptor–ligand interaction is a major pathway often hijacked by tumors to suppress immune control. The aim of this retrospective study was to investigate the prevalence and prognostic roles of programmed cell death -ligand 1 (PD-L1) expression in small cell lung cancer (SCLC). Methods The expression of PD-L1 was evaluated by immunohistochemical analysis in 102 specimens of SCLC. Tumors with staining in over 5% of tumor cells were scored as positive for PD-L1 expression. Survival analysis was performed using the Kaplan–Meier method. Results Expression of PD-L1 in tumor cells was observed in 71.6% (73 of 102) of SCLCs, and was significantly correlated with a limited disease (LD) stage. SCLC patients with PD-L1-positive tumors showed significantly longer overall survival (OS) than those with PD-L1-negative (median OS, 16.3 versus 7.3 months; p < 0.001, respectively). Multivariate analyses demonstrated that a good performance status, LD stage, and expression of PD-L1 were significantly predictive of better OS, independently of other factors. We found no relevance between PD-L1 expression and progression-free survival for first-line treatment in LD- and extensive disease-SCLC patients. Conclusions In patients with SCLC, expression of PD-L1 is positively correlated with a LD stage, and is independently predictive of a favorable outcome.
Referred From: https://dx.doi.org/10.1097/JTO.0000000000000414
Author(s): Riaz SP, LÃ¼chtenborg M, Coupland VH, Spicer J, Peake MD, et al.
Author(s): Meza R, Meernik C, Jeon J, Cote ML
Author(s): Altan M, Chiang AC
Author(s): Shi Y, Xing P, Fan Y, Zhang X, Hu C, et al.
Author(s): Muenst S, Soysal SD, Tzankov A, Hoeller S
Author(s): Ohaegbulam KC, Assal A, Lazar-Molnar E, Yao Y, Zang X
Author(s): Qin T, Zeng YD, Qin G, Xu F, Lu JB, et al.
Author(s): Schmidt LH, KÃ¼mmel A, GÃ¶rlich D, Mohr M, BrÃ¶ckling S, et al.
Author(s): Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, et al.
Author(s): Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, et al.
Author(s): Micke P, Faldum A, Metz T, Beeh KM, Bittinger F, et al.
Author(s): Muenst S, Schaerli AR, Gao F, DÃ¤ster S, Trella E, et al.
Author(s): Schalper KA, Velcheti V, Carvajal D, Wimberly H, Brown J, et al.
Author(s): Ali HR, Glont SE, Blows FM, Provenzano E, Dawson SJ, et al.
Author(s): Wang A, Wang HY, Liu Y, Zhao MC, Zhang HJ, et al.
Author(s): Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, et al.
Author(s): Zhang Y, Wang L, Li Y, Pan Y, Wang R, et al.
Author(s): Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, et al.
Author(s): Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, et al.