Retinal manifestations of Alzheimer's disease

Author(s): Dehabadi MH, Davis BM, Wong TK, Cordeiro MF


Alzheimer's disease (AD) is neurodegenerative condition and most common cause of dementia worldwide. Current criteria for its diagnosis and monitoring rely on subjective, expensive or invasive methods that lack sufficient sensitivity, such that a concrete diagnosis of AD can only be made postmortem. Given the structural similarities of the neuro-retina and central nervous system, researchers have shown many manifestations of AD to be detectible in the retinae of humans and transgenic models of AD. Due to the eye's unique optical properties allowing noninvasive in vivo imaging, the retina could provide a window for the early diagnosis and monitoring of AD long before symptom manifestation.

Similar Articles

Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography

Author(s): Schuman JS, Pedut-Kloizman T, Hertzmark E, Hee MR, Wilkins JR, et al.

Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis

Author(s): Yu JG, Feng YF, Xiang Y, Huang JH, Savini G, et al.

Optical Coherence Tomography in Alzheimer's Disease: A Meta-Analysis

Author(s): Coppola G, Di Renzo A, Ziccardi L, Martelli F, Fadda A, et al.

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice

Author(s): Park SW, Kim JH, Mook-Jung I, Kim KW, Park WJ, et al.

Risk factors for progressive axonal degeneration of the retinal nerve fibre layer in multiple sclerosis patients

Author(s): Garcia-Martin E, Pueyo V, Almarcegui C, Martin J, Ara JR, et al.

Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

Author(s): Ratchford JN, Quigg ME, Conger A, Frohman T, Frohman E, et al.

Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

Author(s): Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, et al.

Optical coherence tomography as a tool to evaluate retinal changes in Parkinson's disease

Author(s): Mailankody P, Battu R, Khanna A, Lenka A, Yadav R, et al.

Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography

Author(s): Albrecht P, Ringelstein M, Müller AK, Keser N, Dietlein T, et al.

Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability

Author(s): Reich DS, Smith SA, Gordon-Lipkin EM, Ozturk A, Caffo BS, et al.