Author(s): Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M,
Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental MI than do sibling wild-type (WT) mice. Animals that survived ligation of the left coronary artery underwent echocardiographic studies after MI; all analyses were performed without knowledge of mouse genotype. By day 8, MMP9 knockout (KO) mice had significantly smaller increases in end-diastolic and end-systolic ventricular dimensions at both midpapillary and apical levels, compared with infarcted WT mice; these differences persisted at 15 days after MI. MMP-9 KO mice had less collagen accumulation in the infarcted area than did WT mice, and they showed enhanced expression of MMP-2, MMP-13, and TIMP-1 and a reduced number of macrophages. We conclude that targeted deletion of the MMP9 gene attenuates LV dilation after experimental MI in mice. The decrease in collagen accumulation and the enhanced expression of other MMPs suggest that MMP-9 plays a prominent role in extracellular matrix remodeling after MI.
Referred From: https://www.jci.org/articles/view/8768
Author(s): Mendis S, Puska P, Norrving B
Author(s): Crea F, Liuzzo G
Author(s): Bentzon JF, Otsuka F, Virmani R, Falk E
Author(s): Moore KJ, Tabas I
Author(s): Yabluchanskiy A, Ma Y, Iyer RP, Hall ME, Lindsey ML
Author(s): Lopes-Virella MF, Virella G
Author(s): Zhang J, Wang D, He S
Author(s): Kalela A, Koivu TA, Höyhtyä M, Jaakkola O, Lehtimäki T
Author(s): Yousuf O, Mohanty BD, Martin SS, Joshi PH, Blaha MJ
Author(s): Raposeiras Roubín S, Barreiro Pardal C, Roubín-Camiña F, Ocaranza Sanchez R, Alvarez Castro E
Author(s): Montalescot G, Sechtem U, Achenbach S, Andreotti F
Author(s): Abrams J
Author(s): Gensini GG
Author(s): Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A
Author(s): Tanboga IH, Topcu S, Aksakal E, Kalkan K, Sevimli S
Author(s): Gibson CM, Lemos JA de, Murphy SA, Marble SJ, McCabe CH
Author(s): Yamashita H, Ehara S, Yoshiyama M, Yoshiyama M, Naruko T
Author(s): Huang H, Mai W, Liu D, Hao Y, Tao J
Author(s): Medeiros AM, von Mühlen CA, Gidlund MA, Bodanese R, Gottlieb MG
Author(s): Moohebati M, Kabirirad V, Ghayour-Mobarhan M, Esmaily H, Tavallaie S
Author(s): Newby AC
Author(s): Dave T, Ezhilan J, Vasnawala H, Somani V
Author(s): Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA
Author(s): Blankenberg S, Rupprecht HJ, Poirier O, Bickel C, Smieja M
Author(s): PopoviÄ S, CanoviÄ
Author(s): Kalela A, Koivu TA, Sisto T, Kanervisto J, Höyhtyä M