Advances in gastropod immunity from the study of the interaction between the snail Biomphalariaglabrata and its parasites: A review of research progress over the last decade

Author(s): Coustau C, Gourbal B, Duval D, Yoshino TP, Adema CM, et al.


This review summarizes the research progress made over the past decade in the field of gastropod immunity resulting from investigations of the interaction between the snail Biomphalaria glabrata and its trematode parasites. A combination of integrated approaches, including cellular, genetic and comparative molecular and proteomic approaches have revealed novel molecular components involved in mediating Biomphalaria immune responses that provide insights into the nature of host-parasite compatibility and the mechanisms involved in parasite recognition and killing. The current overview emphasizes that the interaction between B. glabrata and its trematode parasites involves a complex molecular crosstalk between numerous antigens, immune receptors, effectors and anti-effector systems that are highly diverse structurally and extremely variable in expression between and within host and parasite populations. Ultimately, integration of these molecular signals will determine the outcome of a specific interaction between a B. glabrata individual and its interacting trematodes. Understanding these complex molecular interactions and identifying key factors that may be targeted to impairment of schistosome development in the snail host is crucial to generating new alternative schistosomiasis control strategies.

Similar Articles

Uptake of mass drug administration programme for schistosomiasis control in koome islands, central Uganda

Author(s): Tuhebwe D, Bagonza J, Kiracho EE, Yeka A, Elliott AM, et al.

An unusual case of hematuria in a French family returning from Corsica

Author(s): Brunet J, Pfaff AW, Hansmann Y, Gregorowicz G, Pesson B, et al.

Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity

Author(s): Tamura Y, Torigoe T, Kukita K, Saito K, Okuya K, et al.

Thioredoxin peroxidases from Brugiamalayi

Author(s): Ghosh I, Eisinger SW, Raghavan N, Scott AL

Comparative gene analysis of Biomphalariaglabratahemocytes pre- and post-exposure to miracidia of Schistosomamansoni

Author(s): Raghavan N, Miller AN, Gardner M, FitzGerald PC, Kerlavage AR, et al.

Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereriabancrofti

Author(s): Raghavan N, Freedman DO, Fitzgerald PC, Unnasch TR, Ottesen EA, et al.

Interaction of SchistosomamansoniSporocysts and Hemocytes of Biomphalaria

Author(s): Negrao-Correa D, Mattos AC, Pereira CA, Martins-Souza RL, Coelho PM

The environmental genomics of metazoan thermal adaptation

Author(s): Porcelli D, Butlin RK, Gaston KJ, Joly D, Snook RR