Recommended Conferences

Parkinsons Congress 2022

London, UK

Psychology Health 2022

Amsterdam, Netherlands
 

Microglia in neurodegenerative disease

Author(s): Perry VH, Nicoll JA, Holmes C

Abstract

Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and disease, altering their morphology and phenotype to adopt a so-called activated state in response to pathophysiological brain insults. Morphologically activated microglia, like other tissue macrophages, exist as many different phenotypes, depending on the nature of the tissue injury. Microglial responsiveness to injury suggests that these cells have the potential to act as diagnostic markers of disease onset or progression, and could contribute to the outcome of neurodegenerative diseases. The persistence of activated microglia long after acute injury and in chronic disease suggests that these cells have an innate immune memory of tissue injury and degeneration. Microglial phenotype is also modified by systemic infection or inflammation. Evidence from some preclinical models shows that systemic manipulations can ameliorate disease progression, although data from other models indicates that systemic inflammation exacerbates disease progression. Systemic inflammation is associated with a decline in function in patients with chronic neurodegenerative disease, both acutely and in the long term. The fact that diseases with a chronic systemic inflammatory component are risk factors for Alzheimer disease implies that crosstalk occurs between systemic inflammation and microglia in the CNS.

Similar Articles

Drug harms in the UK: a multicriteria decision analysis

Author(s): Nutt DJ, King LA, Phillips LD

Pharmacological management of alcohol dependence: from mono-therapy to pharmacogenetics and beyond

Author(s): Caputo F, Vignoli T, Grignaschi A, Cibin M, Addolorato G, et al.

Neurocircuitry of addiction

Author(s): Koob GF, Volkow ND

Gamma-hydroxybutyrate (GHB) for treatment of alcohol withdrawal and prevention of relapses

Author(s): Leone MA, Vigna-Taglianti F, Avanzi G, Brambilla R, Faggiano

Understanding opioid reward

Author(s): Fields HL, Margolis EB

Central effects of acamprosate: part 1

Author(s): Dahchour A, De Witte P, Bolo N, Nédélec JF, Muzet M, et al.

Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task

Author(s): Kamarajan C, Porjesz B, Jones KA, Choi K, Chorlian DB, et al.