Author(s): Gujral DM, Shah BN, Chahal NS, Senior R, Harrington KJ, et al.
Carotid arteries frequently receive significant incidental doses of radiation during the treatment of malignant diseases, including head and neck cancer, breast cancer and lymphoma. Vascular injury after treatment may result in carotid artery stenosis and increased risk of neurological sequelae, such as stroke and transient ischaemic attack. The long latent interval from treatment to the development of clinical complications makes investigation of this process difficult, particularly in regard to the design of interventional clinical studies. Nevertheless, there is compelling clinical evidence that radiation contributes to carotid atherosclerosis. This overview examines the effect of radiotherapy on the carotid arteries, the underlying pathological processes and their clinical manifestations. The use of serum biomarkers in risk-prediction models and the potential value of new imaging techniques as tools for defining earlier surrogate end points will also be discussed.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/24188597
Author(s): Lam WW, Leung SF, So NM, Wong KS, Liu KH, et al.
Author(s): Elerding SC, Fernandez RN, Grotta JC, Lindberg RD, Causay LC, et al.
Author(s): Cheng SWK, Ting ACW, Lam LKL, Wei WI
Author(s): Ahuja A, Blatt GL, Guterman LR, Hopkins LN
Author(s): Ohta H, Sakai N, Nagata I, Sakai H, Higashi T, et al.
Author(s): Mubarak NA, Roubin GS, Iyer SS, Gomez CR, Liu MW, et al.
Author(s): Cohen JE, Rajz G, Lylyk P, Hur TB, Gomori JM, et al.
Author(s): Kim PH, Kadkhodayan Y, Derdeyn CP, Moran CJ
Author(s): Ting AC, Cheng SW, Yeung KM, Cheng PW, Lui WM, et al.
Author(s): Stein JS, Jacobson JH
Author(s): Becquemin JP, Gasparino LF, Etienne G
Author(s): Guthaner DF, Schmitz L
Author(s): Julius HJ, Murray GB
Author(s): Kretschmer G, Niederle B, Polterauer P, Waneck R
Author(s): MelliÃ¨re D, Becquemin JP, Berrahal , Desgranges P, Cavillon
Author(s): Hans SS, Tuma
Author(s): Ragaz J, Jackson SM, Le N, Plenderleith IH, Spinelli JJ, et al.
Author(s): Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, et al.
Author(s): Clarke M, Collins R, Darby S, Davies C, Elphinstone P, et al.
Author(s): Halle M, Gabrielsen A, Paulsson-Berne G, Gahm C, Agardh HE, et al.
Author(s): Zhao W, Robbins ME
Author(s): Fonkalsrud EW, Sanchez M, Zerubavel R, Mahoney A
Author(s): Cheng SW, Ting AC, Wu LL
Author(s): Atkinson JLD, SundtJr TM, Dale AJD, Cascino TL, Nichols DA
Author(s): Jones TR, Fuusha JD
Author(s): Kobayashi N, Nakagawa T, Tashiro K, Abe H