Recommended Conferences

Medicinal Plants 2022

Lisbon, Portugal

Traditional Medicine-2022

Singapore City, Singapore
Related Subjects
 

Plumbagin induces apoptosis in Her2 overexpressing breast cancer cells through the mitochondrial-mediated pathway

Author(s): Kawiak A, Zawacka-Pankau J, Lojkowska E

Abstract

Breast cancer is the leading cause of death-related cancers in women. Approximately 30% of breast cancers overexpress the Her2 oncogene, which is associated with a poor prognosis and increased resistance to chemotherapy. Plumbagin (1), a constituent of species in the plant genera Drosera and Plumbago, displays antineoplastic activity toward various cancers. The present study was aimed at determining the anticancer potential of 1 toward Her2-overexpressing breast cancer cells and defining the mode of cell death induced in these cells. The results showed that 1 exhibited high antiproliferative activity toward the Her2-overexpressing cell lines SKBR3 and BT474. The antiproliferative activity of 1 was associated with apoptosis-mediated cell death, as revealed by caspase activation and an increase in the sub-G1 fraction of the cell cycle. Compound 1 increased the levels of the proapoptotic Bcl-2 family of proteins and decreased the level of the antiapoptotic Bcl-2 protein in SKBR3 and BT474 cells. Thus, these findings indicate that 1 induces apoptosis in Her2-overexpressing breast cancers through the mitochondrial-mediated pathway and suggest its potential for further investigation for the treatment of Her2-overexpressing breast cancer.

Similar Articles

Plants as a source of anti-cancer agents

Author(s): GM Cragg, DJ Newman

Anticancer effects of ethanolicneem leaf extract on prostate cancer cell line (PC-3)

Author(s): Kumar S, Suresh PK, Vijayababu MR, Arunkumar A, Arunakaran J

IntImmunopharmacol4:355-66

Author(s): R Baral, Chattopadhyay U ( 2004) Neem (Azadirachtaindica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma

Extract of Azadirachtaindica (Neem) leaf induces apoptosis in 4T1 breast cancer BALB/c mice

Author(s): Othman F, Motalleb G,Peng SLT,Rahmat A, Fakurazi S, et al.

Neem oil limonoids induces p53-independent apoptosis and autophagy

Author(s): Srivastava P, Yadav N, Lella R,Schneider A, Jones A, et al.

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

Author(s): Elumalai P, Gunadharini DN,Senthilkumar K, Banudevi S,Arunkumar R, et al.

Cancer ChemotherPharmacol Jul47:29-34

Author(s): Dale PS, Tamhankar CP, George D, Daftary GV ( 2001) Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects

Plant products protective against cancer

Author(s): Aruna K,Sivaramakrishnan VM

Anticarcinogenic effect of some Indian plant products

Author(s): Aruna K, Sivaramakrishnan VM

Antiproliferative activity of Vietnamese medicinal plants

Author(s): Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, et al.

Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts

Author(s): Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, et al.

Isolation of indole alkaloids from Catharanthusroseus by centrifugal partition chromatography in the pH-zone refining mode

Author(s): Renault JH, Nuzillard JM, Le Crouérour G, Thépenier P, Zèches-Hanrot M, et al.