Recommended Conferences

Medicinal Plants 2022

Lisbon, Portugal

Traditional Medicine-2022

Singapore City, Singapore
Related Subjects
 

Anticancer effects of ethanolicneem leaf extract on prostate cancer cell line (PC-3)

Author(s): Kumar S, Suresh PK, Vijayababu MR, Arunkumar A, Arunakaran J

Abstract

Prostate cancer (PC) is the most prevalent cancer and the leading cause of male cancer death. Azadirachta indica (neem tree) has been used successfully centuries to reduce tumors by herbalists throughout Southeast Asia. Here the present study indicated that an ethanolic extract of neem has been shown to cause cell death of prostate cancer cells (PC-3) by inducing apoptosis as evidenced by a dose-dependent increase in DNA fragmentation and a decrease in cell viability. Western blot studies indicated that treatment with neem extract showed decreased level of Bcl-2, which is anti-apoptotic protein and increased the level of Bax protein. So the neem extract could be potentially effective against prostate cancer treatment.

Similar Articles

Plants as a source of anti-cancer agents

Author(s): GM Cragg, DJ Newman

IntImmunopharmacol4:355-66

Author(s): R Baral, Chattopadhyay U ( 2004) Neem (Azadirachtaindica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma

Extract of Azadirachtaindica (Neem) leaf induces apoptosis in 4T1 breast cancer BALB/c mice

Author(s): Othman F, Motalleb G,Peng SLT,Rahmat A, Fakurazi S, et al.

Neem oil limonoids induces p53-independent apoptosis and autophagy

Author(s): Srivastava P, Yadav N, Lella R,Schneider A, Jones A, et al.

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

Author(s): Elumalai P, Gunadharini DN,Senthilkumar K, Banudevi S,Arunkumar R, et al.

Cancer ChemotherPharmacol Jul47:29-34

Author(s): Dale PS, Tamhankar CP, George D, Daftary GV ( 2001) Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects

Plant products protective against cancer

Author(s): Aruna K,Sivaramakrishnan VM

Anticarcinogenic effect of some Indian plant products

Author(s): Aruna K, Sivaramakrishnan VM

Antiproliferative activity of Vietnamese medicinal plants

Author(s): Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, et al.

Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts

Author(s): Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, et al.

Isolation of indole alkaloids from Catharanthusroseus by centrifugal partition chromatography in the pH-zone refining mode

Author(s): Renault JH, Nuzillard JM, Le Crouérour G, Thépenier P, Zèches-Hanrot M, et al.