Recommended Conferences


Amsterdam, Netherlands


Amsterdam, Netherlands


Amsterdam, Netherlands
Related Subjects

Alteration of lethal effects of gamma rays in Swiss albino mice by Tinosporacordifolia

Author(s): Pahadiya S, Sharma J


Tinospora cordifolia is widely used in Ayurvedic medicines. It is known for its immunomodulatory, antihepatotoxic, antistress and antioxidant properties. It has been used in combination with other plant products to prepare a number of Ayurvedic preparations. The present study was undertaken to evaluate the radioprotective effect of an aqueous extract of Tinospora cordifolia (TC) against (60)Co gamma radiation. Oral administration of TC 5 mg/kg body wt to Swiss albino mice 1 h and 15 days prior to whole body radiation exposure (8 Gy) produced a significant protection in terms of survival percentage. After oral administration of TC 10 mg/kg body wt/day to mice 7 days prior to whole body irradiation (8 Gy) there was no mortality until day 13 and 50% of the animals survived until day 30. Mice exposed to radiation (8 Gy) without TC pretreatment exhibited signs of radiation sickness such as anorexia, lethargy, ruffled hair, diarrhoea and these animals died within 14 days of irradiation. The results from the present study suggest that Tinospora cordifolia has a radioprotective effect in Swiss albino mice, thereby enhancing the survival of mice against a sublethal dose of gamma radiation.

Similar Articles

Plants as a source of anti-cancer agents

Author(s): GM Cragg, DJ Newman

Anticancer effects of ethanolicneem leaf extract on prostate cancer cell line (PC-3)

Author(s): Kumar S, Suresh PK, Vijayababu MR, Arunkumar A, Arunakaran J


Author(s): R Baral, Chattopadhyay U ( 2004) Neem (Azadirachtaindica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma

Extract of Azadirachtaindica (Neem) leaf induces apoptosis in 4T1 breast cancer BALB/c mice

Author(s): Othman F, Motalleb G,Peng SLT,Rahmat A, Fakurazi S, et al.

Neem oil limonoids induces p53-independent apoptosis and autophagy

Author(s): Srivastava P, Yadav N, Lella R,Schneider A, Jones A, et al.

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

Author(s): Elumalai P, Gunadharini DN,Senthilkumar K, Banudevi S,Arunkumar R, et al.

Cancer ChemotherPharmacol Jul47:29-34

Author(s): Dale PS, Tamhankar CP, George D, Daftary GV ( 2001) Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects

Plant products protective against cancer

Author(s): Aruna K,Sivaramakrishnan VM

Anticarcinogenic effect of some Indian plant products

Author(s): Aruna K, Sivaramakrishnan VM

Antiproliferative activity of Vietnamese medicinal plants

Author(s): Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, et al.

Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts

Author(s): Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, et al.

Isolation of indole alkaloids from Catharanthusroseus by centrifugal partition chromatography in the pH-zone refining mode

Author(s): Renault JH, Nuzillard JM, Le Crouérour G, Thépenier P, Zèches-Hanrot M, et al.