Author(s): Pahadiya S, Sharma J
Tinospora cordifolia is widely used in Ayurvedic medicines. It is known for its immunomodulatory, antihepatotoxic, antistress and antioxidant properties. It has been used in combination with other plant products to prepare a number of Ayurvedic preparations. The present study was undertaken to evaluate the radioprotective effect of an aqueous extract of Tinospora cordifolia (TC) against (60)Co gamma radiation. Oral administration of TC 5 mg/kg body wt to Swiss albino mice 1 h and 15 days prior to whole body radiation exposure (8 Gy) produced a significant protection in terms of survival percentage. After oral administration of TC 10 mg/kg body wt/day to mice 7 days prior to whole body irradiation (8 Gy) there was no mortality until day 13 and 50% of the animals survived until day 30. Mice exposed to radiation (8 Gy) without TC pretreatment exhibited signs of radiation sickness such as anorexia, lethargy, ruffled hair, diarrhoea and these animals died within 14 days of irradiation. The results from the present study suggest that Tinospora cordifolia has a radioprotective effect in Swiss albino mice, thereby enhancing the survival of mice against a sublethal dose of gamma radiation.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12748997
Author(s): Takiar R, Nadayil D, Nandakumar A
Author(s): GM Cragg, DJ Newman
Author(s): Kumar S, Suresh PK, Vijayababu MR, Arunkumar A, Arunakaran J
Author(s): R Baral, Chattopadhyay U ( 2004) Neem (Azadirachtaindica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma
Author(s): Udeinya IJ,Shu EN, Quakyi I,Ajayi FO
Author(s): Othman F, Motalleb G,Peng SLT,Rahmat A, Fakurazi S, et al.
Author(s): Srivastava P, Yadav N, Lella R,Schneider A, Jones A, et al.
Author(s): Kavitha K, Priyadarsini RV, Anitha P, Ramalingam K,Sakthivel R, et al.
Author(s): Elumalai P, Gunadharini DN,Senthilkumar K, Banudevi S,Arunkumar R, et al.
Author(s): Sharma C, Andrea J, Goala P, Taher MG,Tahir AR, et al.
Author(s): Dale PS, Tamhankar CP, George D, Daftary GV ( 2001) Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects
Author(s): Popiela T, Kulig J, Hanisch J, Bock PR
Author(s): Tong-PengXu, HuaShen, Ling-Xiang Liu, Yong-QianShu
Author(s): Hsu YL, Cho CY, Kuo PL
Author(s): Kawiak A, Zawacka-Pankau J, Lojkowska E
Author(s): Liu X, Cai W, Niu M, Chong Y, Liu H, et al.
Author(s): Santosh KS, Haruyo I, Gautam S, Ahn-Kwang-Seok, Bharat BA
Author(s): Chen CA, Chang HH, Kao CY, Tsai TH, Chen YJ
Author(s): Prashar R, Kumar A, Banerjee S,Rao AR
Author(s): Prashar R, Kumar A, Hewer A, Cole KJ, Davis W
Author(s): Aruna K,Sivaramakrishnan VM
Author(s): Aruna K, Sivaramakrishnan VM
Author(s): Ganasoundari A, Uma Devi P,Rao BS
Author(s): Leyon PV, Kuttan G
Author(s): Singh N, Singh SM, Shrivastava P
Author(s): Singh SM, Singh N, Shrivastava P
Author(s): Kuo CL, Chou CC, Yung BY
Author(s): Ali H, Dixit S
Author(s): Ueda JY, Tezuka Y, Banskota AH, Le Tran Q, Tran QK, et al.
Author(s): Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, et al.
Author(s): Renault JH, Nuzillard JM, Le CrouÃ©rour G, ThÃ©penier P, ZÃ¨ches-Hanrot M, et al.