The status of serum vitamin D in patients with rheumatoid arthritis and undifferenciated inflammatory arthritis compared with control

Author(s): Heidari B, Hajian Tilaki K, Heidari P


Inadequate vitamin D may be involved in the pathogenesis and or progression of several disorders, including connective tissue diseases. To determine the status of vitamin D in different stages of inflammatory arthritis, the levels of vitamin D in established rheumatoid arthritis (RA) and undifferentiated inflammatory arthritis (UIA) were compared with controls. Patients with RA and UIA entered the study. Serum 25-hydroxyvitamin D (25-OHD) was measured by ELISA method, and concentrations less than 20 ng/ml were considered as deficient levels. In statistical analysis, the Mann–Whitney U test was used for comparing differences between groups and logistic regression analysis with calculation of adjusted odds ratio (OR) was used to determine the association between serum 25-OHD deficiency and disease condition. A total of 108 RA, 39 UIA, and 239 controls were studied. There were no significant differences in mean serum 25-OHD level and frequency of serum 25-OHD deficiency between RA and controls (37 ± 37.7 vs. 33.2 ± 28.6 ng/ml, P = 0.96). But the mean serum 25-OHD level in UIA was significantly lower than in the controls (25.1 ± 23.9 vs. 33.2 ± 28.6 ng ml, P = 0.04). A significant positive association was observed between serum 25-OHD deficiency and UIA (56.4% vs. 35.5%, OR = 2.34, 95% CI, 1.18–4.65, P = 0.021) which remained significant after adjustment for sex and age (adjusted OR = 2.24, 95% CI, 1.01–4.55, P = 0.026). Whereas the association between serum 25-OHD deficiency and RA did not reach statistical significance (40.7% vs. 35.5%, OR = 1.24, 95% CI, 0.78–1.99). These findings indicate higher serum vitamin D deficiency in patients with ongoing arthritis rather than established arthritis. Respecting to deleterious effects of vitamin D deficiency on immune system and progressive nature of UIA, a significant proportion of high risk UIA can be recognized by serum 25-OHD determination.

Similar Articles

Haute Autorite De Sante

Author(s): Strategie de prise en charge en cas de denutrition proteino-energetique chez la personne agee


Author(s): https://www

Vitamine D:effet osseux et extra osseux; recommandations de bon usage

Author(s): Briot K, Audran M, Cortet B, Fardellone P, Marcelli C, et al.

Etude du profil immunitaire de sujets âgés hospitalisés en unité de court séjour gériatrique

Author(s): Crétel E, Veena I, Pierres A, Binana Y, Robert P, et al.

Personal sun exposure and serum 25-hydroxy vitamin D concentrations

Author(s): Nair-Shalliker V, Clements M, Fenech M, Armstrong BK

Vitamin D deficiency

Author(s): Holick MF

Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients

Author(s): Slovik DM, Adams JS, Neer RM, Holick MF, Potts JT


Author(s): http://en

Vitamin D deficiency in veiled Kuwait women

Author(s): El Sonbaty MR, Abdul Ghaffar NU

Clothing preference affects vitamin D status of young women

Author(s): Buyukuslu N, Esin K, Hizli H, Sunal N, Yigit P, et al.

Food sources of vitamin D and their association with 25-hydroxyvitamin D status in Dutch older adults

Author(s): Vaes AMM, Brouwer-Brolsma EM, Van Der Zwaluw NL, Van Wijngaarden JP, Berendsen AAM, et al.

Vitamin D status in Sri Lankans living in Sri Lanka and Norway

Author(s): Meyer HE, Holvik K, Lofthus CM, Tennakoon SU

Serum vitamin D concentrations among elderly people in Europe

Author(s): Van Der Wielen RP, Lowik MR, Van Den Berg H, de Groot LC, Haller J, et al.

Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake

Author(s): Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G

Vitamin D and body composition in the elderly

Author(s): Vitezova A, Muka T, Carola Zillikens M, Voortman T, Uitterlinden AG, et al.

Hypovitaminosis D among rheumatology outpatients in clinical practice

Author(s): Mouyis M, Ostor AJ, Crisp AJ, Ginawi A, Halsall DJ, et al.

Vitamin D status and arterial hypertension: a systematic review

Author(s): Pilz S, Tomaschitz A, Ritz E