Medial collateral ligament healing

Author(s): Frank C, Woo SL, Amiel D, Harwood F, Gomez M, et al.

Abstract

Medial collateral ligament healing without treatment has been studied in a rabbit model. Complete midsubstance gaps were found to heal by distinct scar formation over time. This healing process was fast since the gap was bridged quickly; however, more subtle changes in ap pearance of the healing tissue continued for many months. The ligament "scar" was found to be structur ally abnormal chemically and mechanically even at long- term followup. A plateau in its improvement suggests that the scar may never approach normal ligament characteristics (without treatment). A baseline of liga ment healing by scar formation has been established.

Similar Articles

Biomechanics of tendon injury and repair

Author(s): Lin TW, Cardenas L, Soslowsky LJ

The spatio-temporal dynamics of ligament healing

Author(s): Chamberlain CS, Crowley E, Vanderby R

Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases

Author(s): Galis ZS, Sukhova GK, Kranzhöfer R, Clark S, Libby P

The influence of macrophage depletion on ligament healing

Author(s): Chamberlain CS, Leiferman EM, Frisch KE, Wang S, Yang X, et al.

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages

Author(s): Jovanovic DV, Di Battista JA, Martel-Pelletier J, Jolicoeur FC, He Y, et al.

IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates

Author(s): Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, et al.

Gene profiling of the rat medial collateral ligament during early healing using microarray analysis

Author(s): Chamberlain CS, Brounts SH, Sterken DG, Rolnick KI, Baer GS, et al.

Interleukin-17 promotes angiogenesis and tumor growth

Author(s): Numasaki M, Fukushi J, Ono M, Narula SK, Zavodny PJ, et al.

Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury

Author(s): Barry SP, Ounzain S, McCormick J, Scarabelli TM, Chen-Scarabelli C, et al.

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

Author(s): Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, et al.

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

Author(s): Bronte V, Serafini P, Mazzoni A, Segal DM,Zanovello P

IL-17 Induces Monocyte Migration in Rheumatoid Arthritis

Author(s): Shiva Shahrara, Sarah R. Pickens, Andrea Dorfleutner and Richard M. Pope

Interleukin Expression after Injury and the Effects of Interleukin-1 Receptor Antagonist

Author(s): Connie S. Chamberlain,Ellen M. Leiferman,Kayt E. Frisch,Stacey L. Brickson,William L. Murphy,Geoffrey S. Baer,Ray Vanderby

Interleukin Expression after Injury and the Effects of Interleukin-1 Receptor Antagonist

Author(s): Connie S. Chamberlain,Ellen M. Leiferman,Kayt E. Frisch,Stacey L. Brickson,William L. Murphy,

Interleukin Expression after Injury and the Effects of Interleukin-1 Receptor Antagonist

Author(s): Connie S. Chamberlain,Ellen M. Leiferman,Kayt E. Frisch,Stacey L. Brickson,William L. Murphy,