Author(s): Bernard JY, De Agostini M, Forhan A, de Lauzon-Guillain B, Charles MA, et al.
Long-chain polyunsaturated fatty acids (LC-PUFAs) of the n6 (ω6) and n3 series are essential for the development of a child's brain. Fetal LC-PUFA exposure as well as infant exposure via breast milk depend on the maternal intake of these LC-PUFAs and of their respective dietary precursors (PUFAs). We aimed to investigate the associations between maternal LC-PUFA and PUFA [(LC)PUFA] dietary intake during pregnancy and child neurodevelopment at ages 2 and 3 y. In 1335 mother-child pairs from the EDEN cohort, we evaluated associations between daily maternal (LC)PUFA intake during the last 3 months of pregnancy with the child's language at age 2 y and with different assessments of development at age 3 y. Associations were investigated separately in breastfed and never-breastfed children. We examined interactions between the ratios of n6 and n3 (LC)PUFA intakes (n6:n3 fatty acid ratio) and duration of breastfeeding. Breastfeeding mothers had a lower n6:n3 fatty acid ratio (8.4 vs. 8.8; P = 0.02). Among never-breastfed children (n = 338), we found negative associations between maternal dietary n6:n3 fatty acid ratios and neurodevelopment, as reflected by the child's language at age 2 y (β ± SE = -2.1 ± 0.7; P = 0.001) and development assessed with the Ages and Stages Questionnaire at age 3 y (-1.5 ± 0.8; P = 0.05). Among mothers with a high n6:n3 fatty acid ratio only, breastfeeding duration was positively associated with language at age 2 y (P-interaction < 0.05). This suggests that the ratio between maternal dietary n6 and n3 (LC)PUFA intake possibly influences the child's brain development during fetal life but not during or by breastfeeding. However, breastfeeding might compensate for prenatal imbalance in maternal dietary n6:n3 fatty acid ratio.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/23902952
Author(s): Salley B, Miller A, Bell MA
Author(s): Warren SL, Umylny P, Aron E, Simmens SJ
Author(s): Clifford SM, Hudry K, Elsabbagh M, Charman T, Johnson MH; BASIS Team
Author(s): Zhu P, Sun MS, Hao JH, Chen YJ, Jiang XM, et al.
Author(s): Buss C, Davis EP, Hobel CJ, Sandman CA
Author(s): Monk C, Georgieff MK, Osterholm EA
Author(s): Brunton PJ
Author(s): Tau GZ, Peterson BS
Author(s): Hirst JJ, Walker DW, Yawno T, Palliser HK
Author(s): Loomans EM, van der Stelt O, van Eijsden M, Gemke RJ, Vrijkotte TG, et al.
Author(s): Colaianna M, Schiavone S, Zotti M, Tucci P, Morgese MG, et al.
Author(s): JÃ¸rgensen A
Author(s): Gidron Y, Russ K, Tissarchondou H, Warner J
Author(s): Patki G, Solanki N, Atrooz F, Allam F, Salim S
Author(s): Broyles ST, Staiano AE, Drazba KT, Gupta AK, Sothern M, et al.
Author(s): Myllynen P, Pasanen M, VÃ¤hÃ¤kangas K
Author(s): Chiu CH, Peng CC2, Ker YB3, Chen CC4, Lee A1, et al.
Author(s): Innis SM
Author(s): Janssen CI, Kiliaan AJ2
Author(s): Bradbury J
Author(s): Simopoulos AP
Author(s): Thoits PA
Author(s): Feairheller DL1, Park JY, Sturgeon KM, Williamson ST, Diaz KM, et al.
Author(s): Watters JL, Satia JA, Kupper LL
Author(s): Glad JA, Brink LL, Talbott EO, Lee PC, Xu X, et al.
Author(s): Salihu HM, Ghaji N, Mbah AK, Alio AP, August EM, et al.
Author(s): Suarez EC, Schramm-Sapyta NL2
Author(s): Cohen S, Schwartz JE, Epel E, Kirschbaum C, Sidney S, et al.
Author(s): Geronimus AT, Hicken MT, Pearson JA, Seashols SJ, Brown KL, et al.
Author(s): Suglia SF, Staudenmayer J, Cohen S, Enlow MB, Rich-Edwards JW, et al.
Author(s): von Zglinicki T
Author(s): Wong JY, De Vivo I2, Lin X3, Fang SC4, Christiani DC5
Author(s): Tian R, Hou G, Li D, and Yuan TF
Author(s): Testa M, Quigley BM, Eiden RD
Author(s): Shalowitz MU, Berry CA, Rasinski KA, Dannhausen-Brun CA
Author(s): Myers HF
Author(s): Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, et al.
Author(s): Snook Parrott M, Bodnar LM, Simhan HN, Harger G, Markovic N, et al.
Author(s): Siega-Riz AM1, Bodnar LM, Savitz DA
Author(s): Volgyi E, Carroll KN, Hare ME, Ringwald-Smith K, Piyathilake C, et al.
Author(s): Brunst KJ, Wright RO, DiGioia K, BosquetEnlow M, Fernandez H, et al.
Author(s): Simopoulos AP
Author(s): Parade SH, Leerkes EM
Author(s): Gartstein MA, Gonzalez C, Carranza JA, Ahadi SA, Ye R, et al.
Author(s): Nomaguchi K, House AN
Author(s): Palmer FB, Anand KJ, Graff JC, Murphy LE, Qu Y, et al.
Author(s): Magruder KM, BichunOuyang, Miller S, Tilley BC
Author(s): Powell CA, Walker SP, Chang SM, Grantham-McGregor SM
Author(s): Connolly JD, Goodale MA, Menon RS, Munoz DP
Author(s): Derauf C, LaGasse L, Smith L, Newman E, Shah R, et al.
Author(s): Bridgett DJ, Gartstein MA, Putnam SP, Lance KO, Iddins E, et al.
Author(s): Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF
Author(s): Muris P, Meesters C, Blijlevens P
Author(s): Geronimus AT, Hicken M, Keene D, Bound J
Author(s): Turner RJ, Avison WR
Author(s): Chilcoat HD, Breslau N
Author(s): Blumfield ML, Hure AJ, Macdonald-Wicks L, Smith R, Collins CE
Author(s): McNaughton SA, Hughes MC, Marks GC